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Nature Cell Biology  4, E249 - E250 (2002)
doi:10.1038/ncb1102-e249

Wnt signalling sees spots

Michael Povelones & Roel Nusse

Michael J. Povelones and Roel Nusse are in the Department of Developmental Biology and the Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, CA 94305, USA
rnusse@pmgm2.stanford.edu

The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt−Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the protein. This could represent a critical point for divergence of the Wnt signalling pathway.

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The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
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Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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