News and Views

Nature Cell Biology 4, E249 - E250 (2002)
doi:10.1038/ncb1102-e249

Wnt signalling sees spots

Michael Povelones1 & Roel Nusse1

  1. Michael J. Povelones and Roel Nusse are in the Department of Developmental Biology and the Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, CA 94305, USA
    e-mail: rnusse@pmgm2.stanford.edu

The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt–Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the protein. This could represent a critical point for divergence of the Wnt signalling pathway.

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