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Commentary
Nature Cell Biology  4, E245 - E248 (2002)
doi:10.1038/ncb1102-e245

Synaptic vesicle retrieval: still time for a kiss

Ole Kjaerulff1, Patrik Verstreken2 & Hugo J. Bellen3

1  Ole Kjaerulff is in the Division of Neurophysiology, Department of Medical Physiology, University of Copenhagen, DK-2200 Copenhagen, Denmark.
o.kjaerulff@mfi.ku.dk

2  Patrik Verstreken is in the Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA

3  Hugo J. Bellen is in the Program in Developmental Biology and the Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA

After exocytosis, synaptic vesicles are reformed by slow clathrin-mediated endocytosis. However, evidence also supports the existence of faster retreival mechanisms in neurons, including 'kiss-and-run', where vesicles fuse only partially with the presynaptic membrane before being retrieved. New insights in synaptic vesicle dynamics have been obtained from vesicle imaging and from studies with mutant animals. Recently, measurements of capacitance changes induced by the fusion of single synaptic vesicles in synapses corroborate the hypothesis that kiss-and-run operates in neurons. Here, we review the evidence supporting fast vesicle retrieval and evaluate its role in neurotransmitter release.

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