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Volume 4 Issue 10, October 2002

Xenopus laevis oocytes during meiosis. Microtubules are shown in red, DNA is shown in green.[article, p737]

Volume 4 Issue 10

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  • The Golgi apparatus, in common with other cytoplasmic organelles, must be replicated during the cell cycle. Recent studies using green fluorescent protein (GFP) fusions, suggest that this process may occur by different mechanisms in different organisms. In this issue of Nature Cell Biology, striking new data shows an apparent de novo formation of the Golgi in the daughter cells of budding yeast.

    • Sean Munro
    News & Views

  • The events of mitosis must occur in a precise sequence and in rapid succession to achieve proper chromosome segregation. At each key stage, mitotic checkpoints monitor whether everything is as it should be before proceeding, ensuring orderly progression through mitosis. Now, a new checkpoint has been identified that blocks anaphase onset in response to misoriented mitotic spindles.

    • Dannel McCollum
    News & Views

  • The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.

    • Mark M. Emerson
    • David Van Vactor
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  • The budding of a cargo-laden clathrin-coated pit (CP) from the plasma membrane (PM) during receptor-mediated endocytosis is a paradigm of vesicular transport. A recent study published in Nature Cell Biology helps us visualize the creation of the clathrin-coated vesicle, and the involvement of dynamin and actin as potential 'midwives' in the process. Still, it remains a matter of faith as to exactly when life begins for the coated vesicle.

    • Francesca Santini
    • James H. Keen
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