Lasker celebrates cell biology - pE221

doi:10.1038/ncb1002-e221

Full Text - Lasker celebrates cell biology | PDF (276 KB) - Lasker celebrates cell biology

More than one way to replicate the Golgi apparatus - ppE223 - E224

Sean Munro

doi:10.1038/ncb1002-e223

The Golgi apparatus, in common with other cytoplasmic organelles, must be replicated during the cell cycle. Recent studies using green fluorescent protein (GFP) fusions, suggest that this process may occur by different mechanisms in different organisms. In this issue of Nature Cell Biology, striking new data shows an apparent de novo formation of the Golgi in the daughter cells of budding yeast.

Full Text - More than one way to replicate the Golgi apparatus | PDF (265 KB) - More than one way to replicate the Golgi apparatus

See also: Article by Bevis et al.

First things first: spindle orientation and mitotic progression - ppE225 - E226

Dannel McCollum

doi:10.1038/ncb1002-e225

The events of mitosis must occur in a precise sequence and in rapid succession to achieve proper chromosome segregation. At each key stage, mitotic checkpoints monitor whether everything is as it should be before proceeding, ensuring orderly progression through mitosis. Now, a new checkpoint has been identified that blocks anaphase onset in response to misoriented mitotic spindles.

Full Text - First things first: spindle orientation and mitotic progression | PDF (134 KB) - First things first: spindle orientation and mitotic progression

See also: Brief Communication by Oliferenko & Balasubramanian

Robo is Abl to block N-Cadherin function - ppE227 - E229

Mark M. Emerson & David Van Vactor

doi:10.1038/ncb1002-e227

The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.

Full Text - Robo is Abl to block N-Cadherin function | PDF (132 KB) - Robo is Abl to block N-Cadherin function

See also: Article by Rhee et al.

Bending the membrane - pE229

Barbara Marte

doi:10.1038/ncb1002-e229

Full Text - Bending the membrane | PDF (95 KB) - Bending the membrane

A glimpse of coated vesicle creation? Well almost! - ppE230 - E232

Francesca Santini & James H. Keen

doi:10.1038/ncb1002-e230

The budding of a cargo-laden clathrin-coated pit (CP) from the plasma membrane (PM) during receptor-mediated endocytosis is a paradigm of vesicular transport. A recent study published in Nature Cell Biology helps us visualize the creation of the clathrin-coated vesicle, and the involvement of dynamin and actin as potential 'midwives' in the process. Still, it remains a matter of faith as to exactly when life begins for the coated vesicle.

Full Text - A glimpse of coated vesicle creation? Well almost! | PDF (128 KB) - A glimpse of coated vesicle creation? Well almost!

First mitotic division: getting it right at the start - pE232

Patrick P. L. Tam

doi:10.1038/ncb1002-e232

Full Text - First mitotic division: getting it right at the start | PDF (94 KB) - First mitotic division: getting it right at the start

See also: Brief Communication by Plusa et al.

Small is beautiful - pE233

Paul Clarke reviews The Small GTPase Ran by Mark Rush & Peter D'Eustachio

doi:10.1038/ncb1002-e233

Full Text - Small is beautiful | PDF (99 KB) - Small is beautiful

Slings and arrows - pE234

William M. Bonner reviews In situ detection of DNA damage by Vladimir V. Didenko

doi:10.1038/ncb1002-e234

Full Text - Slings and arrows | PDF (150 KB) - Slings and arrows

Motoring around the Golgi - ppE236 - E242

Victoria J. Allan, Heather M. Thompson & Mark A. McNiven

doi:10.1038/ncb1002-e236

Abstract - | Full Text - Motoring around the Golgi | PDF (686 KB) - Motoring around the Golgi

Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes - pp737 - 742

Laurent H. Perez, Celia Antonio, Stéphane Flament, Isabelle Vernos & Angel R. Nebreda

doi:10.1038/ncb850

Abstract - | Full Text - Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes | PDF (810 KB) - Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes | Supplementary information

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69 - pp743 - 749

Judith Haendeler, Jörg Hoffmann, Verena Tischler, Bradford C. Berk, Andreas M. Zeiher & Stefanie Dimmeler

doi:10.1038/ncb851

Abstract - | Full Text - Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69 | PDF (485 KB) - Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

De novo formation of transitional ER sites and Golgi structures in Pichia pastoris - pp750 - 756

Brooke J. Bevis, Adam T. Hammond, Catherine A. Reinke & Benjamin S. Glick

doi:10.1038/ncb852

Abstract - | Full Text - De novo formation of transitional ER sites and Golgi structures in Pichia pastoris | PDF (2,388 KB) - De novo formation of transitional ER sites and Golgi structures in Pichia pastoris | Supplementary information

See also: News and Views by Munro

Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb - pp757 - 765

B. Nelson Chau, Helena Lobo Borges, Tung-Ti Chen, Anja Masselli, Irina C. Hunton & Jean Y. J. Wang

doi:10.1038/ncb853

Abstract - | Full Text - Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb | PDF (1,980 KB) - Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb

Elimination of host cell PtdIns(4,5)P₂ by bacterial SigD promotes membrane fission during invasion by Salmonella - pp766 - 773

Mauricio R. Terebiznik, Otilia V. Vieira, Sandra L. Marcus, Andrea Slade, Christopher M. Yip, William S. Trimble, Tobias Meyer, B. Brett Finlay & Sergio Grinstein

doi:10.1038/ncb854

Abstract - | Full Text - Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion by Salmonella | PDF (4,433 KB) - Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion by Salmonella | Supplementary information

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon--inducible genes - pp774 - 781

Mei Huang, Feng Qian, Yuanyu Hu, Chengeng Ang, Zhong Li & Zilong Wen

doi:10.1038/ncb855

Abstract - | Full Text - Chromatin-remodelling factor BRG1 selectively activates a subset of interferon--inducible genes | PDF (402 KB) - Chromatin-remodelling factor BRG1 selectively activates a subset of interferon--inducible genes | Supplementary information

Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis - pp782 - 789

Cédric Polesello, Isabelle Delon, Philippe Valenti, Pierre Ferrer & François Payre

doi:10.1038/ncb856

Abstract - | Full Text - Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis | PDF (1,922 KB) - Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis | Supplementary information

Chemomechanical coupling of the forward and backward steps of single kinesin molecules - pp790 - 797

Masayoshi Nishiyama, Hideo Higuchi & Toshio Yanagida

doi:10.1038/ncb857

Abstract - | Full Text - Chemomechanical coupling of the forward and backward steps of single kinesin molecules | PDF (301 KB) - Chemomechanical coupling of the forward and backward steps of single kinesin molecules

Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion - pp798 - 805

Jinseol Rhee, Najmus S. Mahfooz, Carlos Arregui, Jack Lilien, Janne Balsamo & Mark F.A. VanBerkum

doi:10.1038/ncb858

Abstract - | Full Text - Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion | PDF (942 KB) - Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion

See also: News and Views by Emerson & Van Vactor

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components - pp806 - 810

David L. Stenoien, Marilyn Mielke & Michael A. Mancini

doi:10.1038/ncb859

Abstract - | Full Text - Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components | PDF (2,870 KB) - Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components | Supplementary information

Site of the previous meiotic division defines cleavage orientation in the mouse embryo - pp811 - 815

Berenika Plusa, Joanna B. Grabarek, Karolina Piotrowska, David M. Glover & Magdalena Zernicka-Goetz

doi:10.1038/ncb860

Abstract - | Full Text - Site of the previous meiotic division defines cleavage orientation in the mouse embryo | PDF (1,015 KB) - Site of the previous meiotic division defines cleavage orientation in the mouse embryo | Supplementary information

See also: News and Views by Tam

Astral microtubules monitor metaphase spindle alignment in fission yeast - pp816 - 820

Snezhana Oliferenko & Mohan K. Balasubramanian

doi:10.1038/ncb861

Abstract - | Full Text - Astral microtubules monitor metaphase spindle alignment in fission yeast | PDF (933 KB) - Astral microtubules monitor metaphase spindle alignment in fission yeast | Supplementary information

See also: News and Views by McCollum

One-Eyed Pinhead and Spadetail are essential for heart and somite formation - pp821 - 825

Kevin J. P. Griffin & David Kimelman

doi:10.1038/ncb862

Abstract - | Full Text - One-Eyed Pinhead and Spadetail are essential for heart and somite formation | PDF (698 KB) - One-Eyed Pinhead and Spadetail are essential for heart and somite formation

Polyglutamine protein aggregates are dynamic - pp826 - 831

Soojin Kim, Ellen A. A. Nollen, Kazunori Kitagawa, Vytautas P. Bindokas & Richard I. Morimoto

doi:10.1038/ncb863

Abstract - | Full Text - Polyglutamine protein aggregates are dynamic | PDF (930 KB) - Polyglutamine protein aggregates are dynamic | Supplementary information

Corrigendum - Book Review: More than glue - p831

doi:10.1038/ncb864

Full Text - Corrigendum - Book Review: More than glue | PDF (44 KB) - Corrigendum - Book Review: More than glue