Article abstract
Nature Cell Biology 4, 798 - 805 (2002)
Published online: 23 September 2002 | doi:10.1038/ncb858
There is a Corrigendum (November 2002) associated with this Article.
Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion
Jinseol Rhee1, Najmus S. Mahfooz2, Carlos Arregui1, Jack Lilien1, Janne Balsamo1 & Mark F.A. VanBerkum2
Abstract
The formation of axon trajectories requires integration of local adhesive interactions with directional information from attractive and repulsive cues. Here, we show that these two types of information are functionally integrated; activation of the transmembrane receptor Roundabout (Robo) by its ligand, the secreted repulsive guidance cue Slit, inactivates N-cadherin-mediated adhesion. Loss of N-cadherin-mediated adhesion is accompanied by tyrosine phosphorylation of 
-catenin and its loss from the N-cadherin complex, concomitant with the formation of a supramolecular complex containing Robo, Abelson (Abl) kinase and N-cadherin. Local formation of such a receptor complex is an ideal mechanism to steer the growth cone while still allowing adhesion and growth in other directions.
- Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
- Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
Correspondence to: Jack Lilien1 e-mail: jack-lilien@uiowa.edu
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