1. Francesca Santini and James H. Keen are in the Deptartment of Microbiology and Immunology, Cellular Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
   e-mail: Jim.Keen@mail.tju.edu

Abstract

The budding of a cargo-laden clathrin-coated pit (CP) from the plasma membrane (PM) during receptor-mediated endocytosis is a paradigm of vesicular transport. A recent study published in Nature Cell Biology helps us visualize the creation of the clathrin-coated vesicle, and the involvement of dynamin and actin as potential 'midwives' in the process. Still, it remains a matter of faith as to exactly when life begins for the coated vesicle.

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