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Nature Cell Biology 4, E227 - E229 (2002)
doi:10.1038/ncb1002-e227
Robo is Abl to block N-Cadherin function
Mark M. Emerson1 & David Van Vactor1
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Mark Emerson and David Van Vactor are in the Deptartment of Cell Biology and Program in Neuroscience at Harvard Medical School, Boston, MA. 02115-5701, USA
e-mail: davie_vanvactor@hms.harvard.edu
Abstract
The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.
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