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Nature Cell Biology 4, E225 - E226 (2002)
doi:10.1038/ncb1002-e225
First things first: spindle orientation and mitotic progression
Dannel McCollum1
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Dannel McCollum is in the Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, 377 Plantation Street, Worcester, MA 01605, USA
e-mail: Dannel.McCollum@umassmed.edu
Abstract
The events of mitosis must occur in a precise sequence and in rapid succession to achieve proper chromosome segregation. At each key stage, mitotic checkpoints monitor whether everything is as it should be before proceeding, ensuring orderly progression through mitosis. Now, a new checkpoint has been identified that blocks anaphase onset in response to misoriented mitotic spindles.
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