Table of contents
January 2002, Volume 4 No 1 ppE1-93
About the coverEditorial
Advance online publication - pE1
doi:10.1038/ncb0102-e1
Full Text - Advance online publication | PDF (59 KB) - Advance online publication
Commentary
Lymphatic endothelium: a new frontier of metastasis research - ppE2 - E5
Marika J. Karkkainen, Taija Mäkinen & Kari Alitalo
doi:10.1038/ncb0102-e2
The vascular endothelium is a dynamic tissue with many active functions. Until recently, endothelial cell (EC) biology studies have used cultured ECs from various organs; these cell lines are considered representative of the blood vascular endothelium. Very few lymphatic EC lines have been available, and these were derived from lymphatic tumours or large collecting lymphatic ducts. In the past, lymphatic vessels were defined largely by the lack of erythrocytes in their lumen, a lack of junctional complexes and the lack of a well-defined basement membrane. Now that lymphatic-specific vascular endothelial growth factors (VEGF-C and VEGF-D) and molecular cell surface markers such as the VEGFR-3 receptor have been identified, this definition needs to be updated. Recent developments have highlighted the importance of lymphatic ECs, and they could become the next focus for angiogenesis and metastasis research.
Full Text - Lymphatic endothelium: a new frontier of metastasis research | PDF (669 KB) - Lymphatic endothelium: a new frontier of metastasis research
News and Views
Strabismus comes into focus - ppE6 - E8
Jeffrey D. Axelrod
doi:10.1038/ncb0102-e6
At least one member of the Frizzled (Fz) family of receptors, together with the downstream signalling protein Dishevelled, participates in several distinct, yet closely related signal transduction pathways. Activation of the correct signal transduction pathway is critical. Here, a new study suggests that the transmembrane protein Strabismus participates in this decision.
Full Text - Strabismus comes into focus | PDF (337 KB) - Strabismus comes into focus
See also: Article by Park & Moon
A crossbridge too far - ppE8 - E10
James A. Spudich & Ronald S. Rock
doi:10.1038/ncb0102-e8
Myosin V is a marvellous molecular motor that delivers various cargo to specific addresses in eukaryotic cells. Recent developments are leading to a detailed molecular understanding of how this enzyme transduces the chemical energy of ATP hydrolysis into mechanical movement along actin filaments.
Full Text - A crossbridge too far | PDF (565 KB) - A crossbridge too far
See also: Article by Veigel et al.
Finding the path less followed - pE10
Alison Schuldt
doi:10.1038/ncb0102-e10
Full Text - Finding the path less followed | PDF (466 KB) - Finding the path less followed
Novel effector function for an old receptor - ppE11 - E12
Rüdiger Klein
doi:10.1038/ncb0102-e11
Integrins are cell surface receptors for extracellular matrix proteins and, as such, regulate adhesive cell–matrix interactions. New findings indicate that the
4 integrin subunit can also function as a signalling effector for the activated receptor tyrosine kinase Met and enhance invasive growth independent of its adhesive role.
Full Text - Novel effector function for an old receptor | PDF (265 KB) - Novel effector function for an old receptor
Reach for the stars - pE12
Sarah Greaves
doi:10.1038/ncb0102-e12
Full Text - Reach for the stars | PDF (197 KB) - Reach for the stars
Book Reviews
Dictyostelium in focus - pE13
Peter A. Thomason reviews Dictyostelium: Evolution, Cell Biology, and the Development of Multicellularity by Richard H. Kessin
doi:10.1038/ncb0102-e13
Full Text - Dictyostelium in focus | PDF (165 KB) - Dictyostelium in focus
Signal transduction according to the book - pE14
John D. Scott reviews Protein Modules in Cellular Signaling by Ludwig Heilmeyer & Peter Friedrich
doi:10.1038/ncb0102-e14
Full Text - Signal transduction according to the book | PDF (119 KB) - Signal transduction according to the book
Technology Review
Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins - ppE15 - E20
Peter van Roessel & Andrea H. Brand
doi:10.1038/ncb0102-e15
Abstract - | Full Text - Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins | PDF (273 KB) - Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins
Articles
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 - pp1 - 10
Thomas G. Hofmann, Andreas Möller, Hüseyin Sirma, Hanswalter Zentgraf, Yoichi Taya, Wulf Dröge, Hans Will & M. Lienhard Schmitz
doi:10.1038/ncb715
Abstract - | Full Text - Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 | PDF (702 KB) - Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 | Supplementary information
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis - pp11 - 19
Gabriella D'Orazi, Barbara Cecchinelli, Tiziana Bruno, Isabella Manni, Yuichiro Higashimoto, Shin'ichi Saito, Monica Gostissa, Sabrina Coen, Alessandra Marchetti, Giannino Del Sal, Giulia Piaggio, Maurizio Fanciulli, Ettore Appella & Silvia Soddu
doi:10.1038/ncb714
Abstract - | Full Text - Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis | PDF (442 KB) - Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos - pp20 - 25
Maiyon Park & Randall T. Moon
doi:10.1038/ncb716
Abstract - | Full Text - The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos | PDF (1,154 KB) - The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
See also: News and Views by Axelrod
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair - pp26 - 31
Agatha Schwarz, Sonja Ständer, Mark Berneburg, Markus Böhm, Dagmar Kulms, Harry van Steeg, Karin Grosse-Heitmeyer, Jean Krutmann & Thomas Schwarz
doi:10.1038/ncb717
Abstract - | Full Text - Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair | PDF (264 KB) - Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast - pp32 - 41
Marie Evangelista, David Pruyne, David C. Amberg, Charles Boone & Anthony Bretscher
doi:10.1038/ncb718
Abstract - | Full Text - Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast | PDF (4,532 KB) - Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast
Yeast formins regulate cell polarity by controlling the assembly of actin cables - pp42 - 50
Isabelle Sagot, Saskia K. Klee & David Pellman
doi:10.1038/ncb719
Abstract - | Full Text - Yeast formins regulate cell polarity by controlling the assembly of actin cables | PDF (473 KB) - Yeast formins regulate cell polarity by controlling the assembly of actin cables
TGF-
induces apoptosis through Smad-mediated expression of DAP-kinase - pp51 - 58
Chuan-Wei Jang, Chun-Hau Chen, Chun-Chieh Chen, Jia-yun Chen, Yi-Hsien Su & Ruey-Hwa Chen
doi:10.1038/ncb731
Abstract - | Full Text - TGF-
induces apoptosis through Smad-mediated expression of DAP-kinase | PDF (402 KB) - TGF-
induces apoptosis through Smad-mediated expression of DAP-kinase | Supplementary information
The gated gait of the processive molecular motor, myosin V - pp59 - 65
Claudia Veigel, Fei Wang, Marc L. Bartoo, James R. Sellers & Justin E. Molloy
doi:10.1038/ncb732
Abstract - | Full Text - The gated gait of the processive molecular motor, myosin V | PDF (666 KB) - The gated gait of the processive molecular motor, myosin V
See also: News and Views by Spudich & Rock
The exocyst is a Ral effector complex - pp66 - 72
Serge Moskalenko, Dale O. Henry, Carine Rosse, Gladys Mirey, Jacques H. Camonis & Michael A. White
doi:10.1038/ncb728
Abstract - | Full Text - The exocyst is a Ral effector complex | PDF (554 KB) - The exocyst is a Ral effector complex
Brief Communications
The exocyst complex binds the small GTPase RalA to mediate filopodia formation - pp73 - 78
Kazuhiro Sugihara, Shiro Asano, Kenichi Tanaka, Akihiro Iwamatsu, Katsuya Okawa & Yasutaka Ohta
doi:10.1038/ncb720
Abstract - | Full Text - The exocyst complex binds the small GTPase RalA to mediate filopodia formation | PDF (587 KB) - The exocyst complex binds the small GTPase RalA to mediate filopodia formation | Supplementary information
Association of human TFIID–promoter complexes with silenced mitotic chromatin in vivo - pp79 - 82
Rossitza Christova & Thomas Oelgeschläger
doi:10.1038/ncb733
Abstract - | Full Text - Association of human TFIID–promoter complexes with silenced mitotic chromatin in vivo | PDF (333 KB) - Association of human TFIID–promoter complexes with silenced mitotic chromatin in vivo
A small-molecule inhibitor of skeletal muscle myosin II - pp83 - 88
A. Cheung, J. A. Dantzig, S. Hollingworth, S. M. Baylor, Y.E. Goldman, T. J. Mitchison & A. F. Straight
doi:10.1038/ncb734
Abstract - | Full Text - A small-molecule inhibitor of skeletal muscle myosin II | PDF (505 KB) - A small-molecule inhibitor of skeletal muscle myosin II | Supplementary information
Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast - pp89 - 93
Nobuhiro Nonaka, Tomoya Kitajima, Shihori Yokobayashi, Guoping Xiao, Masayuki Yamamoto, Shiv I. S. Grewal & Yoshinori Watanabe
doi:10.1038/ncb739
Abstract - | Full Text - Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast | PDF (505 KB) - Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast | Supplementary information


