Article abstract
Nature Cell Biology 4, 66 - 72 (2001)
Published online: 10 December 2001 | doi:10.1038/ncb728
The exocyst is a Ral effector complex
Serge Moskalenko1, Dale O. Henry1, Carine Rosse2, Gladys Mirey2, Jacques H. Camonis2 & Michael A. White1
Abstract
Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for establishing and maintaining cell polarity, neurite differentiation and regulated exocytosis. The exocyst is a multisubunit complex required for vectorial targeting of a subset of secretory vesicles. Mechanisms that regulate the activity of this complex in mammals are unknown. Here we show that Sec5, an integral component of the exocyst, is a direct target for activated Ral GTPases. Ral GTPases regulate targeting of basolateral proteins in epithelial cells, secretagogue-dependent exocytosis in neuroendocrine cells and assembly of exocyst complexes. These observations define Ral GTPases as critical regulators of vesicle trafficking.
- Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235-9039, USA
- Institute Curie, INSERM U-528, 75248 Paris, France
Correspondence to: Michael A. White1 e-mail: Michael.white@UTSouthwestern.edu
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