News and Views

Nature Cell Biology 4, E8 - E10 (2002)
doi:10.1038/ncb0102-e8

A crossbridge too far

James A. Spudich1 & Ronald S. Rock1

  1. James A. Spudich and Ronald S. Rock are at the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA

Myosin V is a marvellous molecular motor that delivers various cargo to specific addresses in eukaryotic cells. Recent developments are leading to a detailed molecular understanding of how this enzyme transduces the chemical energy of ATP hydrolysis into mechanical movement along actin filaments.

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