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Nature Cell Biology 4, E11 - E12 (2002)
doi:10.1038/ncb0102-e11
Novel effector function for an old receptor
Rüdiger Klein1
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Rüdiger Klein is in the Max-Planck Institute of Neurobiology, Department of Molecular Neurobiology, Am Klopferspitz 18A, D-82152 Martinsried, Germany.
e-mail: rklein@neuro.mpg.de
Abstract
Integrins are cell surface receptors for extracellular matrix proteins and, as such, regulate adhesive cell–matrix interactions. New findings indicate that the 
4 integrin subunit can also function as a signalling effector for the activated receptor tyrosine kinase Met and enhance invasive growth independent of its adhesive role.
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