The price of a PhD - pE199

doi:10.1038/ncb0901-e199

Full Text - The price of a PhD | PDF (108 KB) - The price of a PhD

A new view of mRNA export: Separating the wheat from the chaff - ppE201 - E204

Robin Reed & Keith Magni

doi:10.1038/ncb0901-e201

Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins — the hnRNP proteins — have a key role in exporting mRNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export factor ALY, which are recruited to the mRNA during pre-mRNA splicing. These studies, together with older work on hnRNP particles and assembly of the spliceosome, lead us to a new view of mRNA export. In our model, the non-hnRNP factors form a splicing-dependent mRNP complex that specifically targets mature mRNA for export, while hnRNP proteins retain introns in the nucleus. A machinery that is conserved between yeast and higher eukaryotes functions to export the mRNA.

Full Text - A new view of mRNA export: Separating the wheat from the chaff | PDF (239 KB) - A new view of mRNA export: Separating the wheat from the chaff

Skinny dipping for stem cells - ppE205 - E206

Jonathan Slack

doi:10.1038/ncb0901-e205

Stem cells have been big news for the past couple of years and yet they remain remarkably inscrutable in terms of declaring their true nature and identity. On p. 778–784 of this issue, Toma et al. describe the identification of a new type of stem cell from the dermis of the skin, called SKP cells. These can be converted into several differentiated cell types in vitro, including neurons, and might become a source of cells for therapeutic tissue repair.

Full Text - Skinny dipping for stem cells | PDF (580 KB) - Skinny dipping for stem cells

Brain dead (or alive) - pE206

Valerie Depraetere

doi:10.1038/ncb0901-e206

Full Text - Brain dead (or alive) | PDF (430 KB) - Brain dead (or alive)

Separase anxiety: dissolving the sister bond and more - ppE207 - E209

David Pellman & Michael F. Christman

doi:10.1038/ncb0901-e207

Separase is a protease that cleaves the bonds between sister chromatids during cell division. Until now, separase was thought to be a somewhat repressed protease, cleaving only a few substrates in a very controlled fashion. New findings in this issue raise the possibility that separase has some of the atavistic impulses that characterize caspases, its more destructive relatives.

Full Text - Separase anxiety: dissolving the sister bond and more | PDF (426 KB) - Separase anxiety: dissolving the sister bond and more

The lethality of sex - pE208

Sarah Greaves

doi:10.1038/ncb0901-e208

Full Text - The lethality of sex | PDF (307 KB) - The lethality of sex

EGF receptors as transcription factors: ridiculous or sublime? - ppE209 - E211

Mark G. Waugh & J. Justin Hsuan

doi:10.1038/ncb0901-e209

The notion that a transmembrane receptor at the cell surface can somehow reappear as a transcription factor in the nucleus is bound to be controversial. However, there are two reported examples of this. If this hypothesis can withstand the inevitable and necessary battery of additional empirical tests then our understanding of signal transduction needs to move in a new direction.

Full Text - EGF receptors as transcription factors: ridiculous or sublime? | PDF (307 KB) - EGF receptors as transcription factors: ridiculous or sublime?

Selling cellular gels - pE213

Michael. W. Klymkowsky reviews Cells, Gels and the Engines of Life by G. H. Pollack

doi:10.1038/ncb0901-e213

Full Text - Selling cellular gels | PDF (407 KB) - Selling cellular gels

A rise from obscurity — proteoglycans in focus - pE214

Jeremy Turnbull reviews Proteoglycans: Structure, Biology and Molecular Interactions by Renato Iozzo

doi:10.1038/ncb0901-e214

Full Text - A rise from obscurity — proteoglycans in focus | PDF (301 KB) - A rise from obscurity — proteoglycans in focus

The SMRT route to transcriptional repression - pE215

Jeff Wrana reviews Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression by Martin L. Privalsky

doi:10.1038/ncb0901-e215

Full Text - The SMRT route to transcriptional repression | PDF (337 KB) - The SMRT route to transcriptional repression

Tracing the lineage of tracing cell lineages - ppE216 - E218

Claudio D. Stern & Scott E. Fraser

doi:10.1038/ncb0901-e216

Abstract - | Full Text - Tracing the lineage of tracing cell lineages | PDF (1,091 KB) - Tracing the lineage of tracing cell lineages

Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19 - pp771 - 777

Matthew Sullivan, Christine Lehane & Frank Uhlmann

doi:10.1038/ncb0901-771

Abstract - | Full Text - Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19 | PDF (428 KB) - Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19

Isolation of multipotent adult stem cells from the dermis of mammalian skin - pp778 - 784

Jean G. Toma, Mahnaz Akhavan, Karl J. L. Fernandes, Fanie Barnabé-Heider, Abbas Sadikot, David R. Kaplan & Freda D. Miller

doi:10.1038/ncb0901-778

Abstract - | Full Text - Isolation of multipotent adult stem cells from the dermis of mammalian skin | PDF (1,055 KB) - Isolation of multipotent adult stem cells from the dermis of mammalian skin

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini - pp785 - 792

Senthil K. Muthuswamy, Dongmei Li, Sophie Lelievre, Mina J. Bissell & Joan S. Brugge

doi:10.1038/ncb0901-785

Abstract - | Full Text - ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini | PDF (2,787 KB) - ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini | Supplementary information

Pin1 regulates turnover and subcellular localization of -catenin by inhibiting its interaction with APC - pp793 - 801

Akihide Ryo, Masafumi Nakamura, Gerburg Wulf, Yih-Cherng Liou & Kun Ping Lu

doi:10.1038/ncb0901-793

Abstract - | Full Text - Pin1 regulates turnover and subcellular localization of -catenin by inhibiting its interaction with APC | PDF (702 KB) - Pin1 regulates turnover and subcellular localization of -catenin by inhibiting its interaction with APC | Supplementary information

Nuclear localization of EGF receptor and its potential new role as a transcription factor - pp802 - 808

Shiaw-Yih Lin, Keishi Makino, Weiya Xia, Angabin Matin, Yong Wen, Ka Yin Kwong, Lilly Bourguignon & Mien-Chie Hung

doi:10.1038/ncb0901-802

Abstract - | Full Text - Nuclear localization of EGF receptor and its potential new role as a transcription factor | PDF (561 KB) - Nuclear localization of EGF receptor and its potential new role as a transcription factor

Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events - pp809 - 815

Erica M. Selva, Kyoungja Hong, Gyeong-Hun Baeg, Stephen M. Beverley, Salvatore J. Turco, Norbert Perrimon & Udo Häcker

doi:10.1038/ncb0901-809

Abstract - | Full Text - Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events | PDF (3,118 KB) - Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events

UDP–sugar transporter implicated in glycosylation and processing of Notch - pp816 - 822

Satoshi Goto, Misako Taniguchi, Masatoshi Muraoka, Hidenao Toyoda, Yukiko Sado, Masao Kawakita & Shigeo Hayashi

doi:10.1038/ncb0901-816

Abstract - | Full Text - UDP–sugar transporter implicated in glycosylation and processing of Notch | PDF (880 KB) - UDP–sugar transporter implicated in glycosylation and processing of Notch

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning - pp823 - 830

Sarah K. Runswick, Mike J. O'Hare, Louise Jones, Charles H. Streuli & David R. Garrod

doi:10.1038/ncb0901-823

Abstract - | Full Text - Desmosomal adhesion regulates epithelial morphogenesis and cell positioning | PDF (1,987 KB) - Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly - pp831 - 838

Lucy Erin O'Brien, Tzuu-Shuh Jou, Anne L. Pollack, Qihang Zhang, Steen H. Hansen, Peter Yurchenco & Keith E. Mostov

doi:10.1038/ncb0901-831

Abstract - | Full Text - Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly | PDF (604 KB) - Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

Heat-shock protein 70 antagonizes apoptosis-inducing factor - pp839 - 843

Luigi Ravagnan, Sandeep Gurbuxani, Santos A. Susin, Carine Maisse, Eric Daugas, Naoufal Zamzami, Tak Mak, Marja Jäättelä, Josef M. Penninger, Carmen Garrido & Guido Kroemer

doi:10.1038/ncb0901-839

Abstract - | Full Text - Heat-shock protein 70 antagonizes apoptosis-inducing factor | PDF (551 KB) - Heat-shock protein 70 antagonizes apoptosis-inducing factor

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex - pp844 - 847

Muriel Grenon, Chris Gilbert & Noel F. Lowndes

doi:10.1038/ncb0901-844

Abstract - | Full Text - Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex | PDF (486 KB) - Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex | Supplementary information

A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila - pp848 - 851

Karen Guillemin, Tyler Williams & Mark A. Krasnow

doi:10.1038/ncb0901-848

Abstract - | Full Text - A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila | PDF (1,698 KB) - A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila

Four-dimensional imaging and quantitative reconstruction to analyse complex spatiotemporal processes in live cells - pp852 - 855

Daniel Gerlich, Joël Beaudouin, Matthias Gebhard, Jan Ellenberg & Roland Eils

doi:10.1038/ncb0901-852

Abstract - | Full Text - Four-dimensional imaging and quantitative reconstruction to analyse complex spatiotemporal processes in live cells | PDF (663 KB) - Four-dimensional imaging and quantitative reconstruction to analyse complex spatiotemporal processes in live cells | Supplementary information

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells - pp856 - 859

Samantha Gruenheid, Rebekah DeVinney, Friedhelm Bladt, Danika Goosney, Sigal Gelkop, Gerald D. Gish, Tony Pawson & B. Brett Finlay

doi:10.1038/ncb0901-856

Abstract - | Full Text - Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells | PDF (785 KB) - Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells | Supplementary information