Article abstract
Nature Cell Biology 3, 778 - 784 (2001)
Published online: 13 August 2001 | doi:10.1038/ncb0901-778
Isolation of multipotent adult stem cells from the dermis of mammalian skin
Jean G. Toma1, Mahnaz Akhavan1,4, Karl J. L. Fernandes1,4,2, Fanie Barnabé-Heider1, Abbas Sadikot3, David R. Kaplan1,2 & Freda D. Miller1
Abstract
We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle cells and adipocytes. Similar precursors that produce neuron-specific proteins upon differentiation can be isolated from adult human scalp. Because these cells (termed SKPs for skin-derived precursors) generate both neural and mesodermal progeny, we propose that they represent a novel multipotent adult stem cell and suggest that skin may provide an accessible, autologous source of stem cells for transplantation.
- Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
- Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
- Division of Neurosurgery, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
- These authors contributed equally to this work
Correspondence to: Freda D. Miller1 e-mail: mdfm@musica.mcgill.ca
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS RESEARCH |
