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Brief Communication

Nature Cell Biology 3, 755–760 (1 August 2001) | doi:10.1038/35087075

The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling

Anna Elisabetta Salcini , Massimo Antonio Hilliard , Assunta Croce , Salvatore Arbucci , Paola Luzzi , Carlo Tacchetti , Laurie Daniell , Pietro De Camilli , Pier Giuseppe Pelicci , Pier Paolo Di Fiore & Paolo Bazzicalupo

Eps15 represents the prototype of a family of evolutionarily conserved proteins that are characterized by the presence of the EH domain, a protein–protein interaction module, and that are involved in many aspects of intracellular vesicular sorting. Although biochemical and functional studies have implicated Eps15 in endocytosis, its function in the endocytic machinery remains unclear.