Deep impact? - pE171

doi:10.1038/35087096

Full Text - Deep impact? | PDF (63 KB) - Deep impact?

Which Ras rides the raft? - pE172

Michael A. White & Richard G. W. Anderson

doi:10.1038/35087098

Full Text - Which Ras rides the raft? | PDF (76 KB) - Which Ras rides the raft?

Which Ras rides the raft? - Reply - pE172

Ian A Prior, Robert G Parton & John F Hancock

doi:10.1038/35087100

Full Text - Which Ras rides the raft? - Reply | PDF (76 KB) - Which Ras rides the raft? - Reply

Does endo-symbiosis explain the origin of the nucleus? - pE173

Anthony Poole & David Penny

doi:10.1038/35087102

Full Text - Does endo-symbiosis explain the origin of the nucleus? | PDF (75 KB) - Does endo-symbiosis explain the origin of the nucleus?

Does endo-symbiosis explain the origin of the nucleus? - pE173

Carmen Rotte & William Martin

doi:10.1038/35087104

Full Text - Does endo-symbiosis explain the origin of the nucleus? | PDF (75 KB) - Does endo-symbiosis explain the origin of the nucleus?

Does endo-symbiosis explain the origin of the nucleus? - Reply - ppE173 - E174

Takao Shinozawa, Tokumasa Horiike & Kazuo Hamada

doi:10.1038/35087106

Full Text - Does endo-symbiosis explain the origin of the nucleus? - Reply | PDF (1,160 KB) - Does endo-symbiosis explain the origin of the nucleus? - Reply

DNA microarrays and beyond: completing the journey from tissue to cell - ppE175 - E178

Jason C. Mills, Kevin A. Roth, Ross L. Cagan & Jeffrey I. Gordon

doi:10.1038/35087108

For the cell biologist, identifying changes in gene expression using DNA microarrays is just the start of a long journey from tissue to cell. We discuss how chip users can first filter noise (false-positives) from daunting microarray datasets. Combining laser capture microdissection with real-time polymerase chain reaction and reverse transcription is a helpful follow-up step that allows expression of selected genes to be quantified in populations of recovered cells. The voyage from chip to single cell can be completed using sensitive new in situ hybridization and immunohistochemical methods based on tyramide signal amplification.

Full Text - DNA microarrays and beyond: completing the journey from tissue to cell | PDF (1,637 KB) - DNA microarrays and beyond: completing the journey from tissue to cell

PX domains: attracted by phosphoinositides - ppE179 - E182

Anne Simonsen & Harald Stenmark

doi:10.1038/35087112

Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive, has been demonstrated to bind phosphoinositides. The interactions of PX-domain-containing proteins with specific phosphoinositides are critical for cellular activities such as microbial killing and membrane trafficking.

Full Text - PX domains: attracted by phosphoinositides | PDF (336 KB) - PX domains: attracted by phosphoinositides

Getting activated with poly-ubiquitination - pE181

Valerie Depraetere

doi:10.1038/35087116

Full Text - Getting activated with poly-ubiquitination | PDF (183 KB) - Getting activated with poly-ubiquitination

The origin of CDK regulation - ppE182 - E184

Anatoliy Li & J. Julian Blow

doi:10.1038/35087119

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

Full Text - The origin of CDK regulation | PDF (1,506 KB) - The origin of CDK regulation

All for one and one for all - pE184

Sarah Greaves

doi:10.1038/35087123

Full Text - All for one and one for all | PDF (1,283 KB) - All for one and one for all

Signalling and endocytosis: Wnt breaks down on back roads - ppE185 - E186

Matthew Scott

doi:10.1038/35087126

How are Wnt signals made effective in only the right times and places? New studies of the asymmetrical influences of Wnt signals originating from a source show the importance of differential signal degradation and regulated endocytosis.

Full Text - Signalling and endocytosis: Wnt breaks down on back roads | PDF (141 KB) - Signalling and endocytosis: Wnt breaks down on back roads

A Primer to proliferation - pE187

Michael Brandeis reviews Principles of Cell Proliferation by

doi:10.1038/35087129

Full Text - A Primer to proliferation | PDF (265 KB) - A Primer to proliferation

Quo vadis with the Q tracts - pE188

F. Ulrich Hartl & Peter Breuer review Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects by

doi:10.1038/35087132

Full Text - Quo vadis with the Q tracts | PDF (391 KB) - Quo vadis with the Q tracts

Getting down to basics with actin - pE189

Henry Higgs reviews Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins by

doi:10.1038/35087135

Full Text - Getting down to basics with actin | PDF (507 KB) - Getting down to basics with actin

Navigating gene expression using microarrays — a technology review - ppE190 - E195

Almut Schulze & Julian Downward

doi:10.1038/35087138

Abstract - | Full Text - Navigating gene expression using microarrays — a technology review | PDF (1,163 KB) - Navigating gene expression using microarrays — a technology review

Greasing the wheels of secretory transport - ppE196 - E198

Jeremy W. Thorner

doi:10.1038/35087142

Abstract - | Full Text - Greasing the wheels of secretory transport | PDF (100 KB) - Greasing the wheels of secretory transport

SV2 modulates the size of the readily releasable pool of secretory vesicles - pp691 - 698

Tao Xu & Sandra M. Bajjalieh

doi:10.1038/35087000

Abstract - | Full Text - SV2 modulates the size of the readily releasable pool of secretory vesicles | PDF (558 KB) - SV2 modulates the size of the readily releasable pool of secretory vesicles

ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity - pp699 - 707

Julie Fradelizi, Vincent Noireaux, Julie Plastino, Bernadette Menichi, Daniel Louvard, Cécile Sykes, Roy M. Golsteyn & Evelyne Friederich

doi:10.1038/35087009

Abstract - | Full Text - ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity | PDF (1,056 KB) - ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity | Supplementary information

TGF--induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation - pp708 - 714

Riki Perlman, William P. Schiemann, Mary W. Brooks, Harvey F. Lodish & Robert A. Weinberg

doi:10.1038/35087019

Abstract - | Full Text - TGF--induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation | PDF (232 KB) - TGF--induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

Triggering ubiquitination of a CDK inhibitor at origins of DNA replication - pp715 - 722

Laura Furstenthal, Craig Swanson, Brett K. Kaiser, Adam G. Eldridge & Peter K. Jackson

doi:10.1038/35087026

Abstract - | Full Text - Triggering ubiquitination of a CDK inhibitor at origins of DNA replication | PDF (577 KB) - Triggering ubiquitination of a CDK inhibitor at origins of DNA replication

mDia mediates Rho-regulated formation and orientation of stable microtubules - pp723 - 729

Alexander F. Palazzo, Tiffani A. Cook, Arthur S. Alberts & Gregg G. Gundersen

doi:10.1038/35087035

Abstract - | Full Text - mDia mediates Rho-regulated formation and orientation of stable microtubules | PDF (1,951 KB) - mDia mediates Rho-regulated formation and orientation of stable microtubules

The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions - pp730 - 739

Michael D. Blower & Gary H. Karpen

doi:10.1038/35087045

Abstract - | Full Text - The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions | PDF (1,891 KB) - The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions | Supplementary information

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation - pp740 - 744

Ren Ming Dai & Chou-Chi H. Li

doi:10.1038/35087056

Abstract - | Full Text - Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation | PDF (912 KB) - Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation | Supplementary information

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1 - pp745 - 750

Faris Farassati, An-Dao Yang & Patrick W. K. Lee

doi:10.1038/35087061

Abstract - | Full Text - Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1 | PDF (1,221 KB) - Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1

Nicastrin binds to membrane-tethered Notch - pp751 - 754

Fusheng Chen, Gang Yu, Shigeki Arawaka, Masaki Nishimura, Toshitaka Kawarai, Haung Yu, Anurag Tandon, Agnes Supala, You Qiang Song, Ekaterina Rogaeva, Paul Milman, Christine Sato, Cong Yu, Christopher Janus, Julie Lee, Lixin Song, Lili Zhang, Paul E. Fraser & P. H. St George-Hyslop

doi:10.1038/35087069

Abstract - | Full Text - Nicastrin binds to membrane-tethered Notch | PDF (472 KB) - Nicastrin binds to membrane-tethered Notch | Supplementary information

The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling - pp755 - 760

Anna Elisabetta Salcini, Massimo Antonio Hilliard, Assunta Croce, Salvatore Arbucci, Paola Luzzi, Carlo Tacchetti, Laurie Daniell, Pietro De Camilli, Pier Giuseppe Pelicci, Pier Paolo Di Fiore & Paolo Bazzicalupo

doi:10.1038/35087075

Abstract - | Full Text - The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling | PDF (3,538 KB) - The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling | Supplementary information

Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I - pp761 - 766

Ignacio Prieto, José A. Suja, Nieves Pezzi, Leonor Kremer, Carlos Martínez-A., Julio S. Rufas & José L. Barbero

doi:10.1038/35087082

Abstract - | Full Text - Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I | PDF (972 KB) - Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I

Reproducible but dynamic positioning of DNA in chromosomes during mitosis - pp767 - 770

Steffen Dietzel & Andrew S. Belmont

doi:10.1038/35087089

Abstract - | Full Text - Reproducible but dynamic positioning of DNA in chromosomes during mitosis | PDF (495 KB) - Reproducible but dynamic positioning of DNA in chromosomes during mitosis | Supplementary information