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Brief Communication
Nature Cell Biology 3, 751–754 (1 August 2001) | doi:10.1038/35087069
Nicastrin binds to membrane-tethered Notch
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Abstract
The presenilins and nicastrin, a type 1 transmembrane glycoprotein, form high molecular weight complexes that are involved in cleaving the β-amyloid precursor protein (βAPP) and Notch in their transmembrane domains. The former process (termed γ-secretase cleavage) generates amyloid β-peptide (Aβ), which is involved in the pathogenesis of Alzheimer's disease.
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