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Nature Cell Biology 3, E179 - E182 (2001)
doi:10.1038/35087112
PX domains: attracted by phosphoinositides
Anne Simonsen1 & Harald Stenmark1
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Anne Simonsen and Harald Stenmark are in the Department of Biochemistry, Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.
e-mail: stenmark@ulrik.uio.no
Abstract
Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive, has been demonstrated to bind phosphoinositides. The interactions of PX-domain-containing proteins with specific phosphoinositides are critical for cellular activities such as microbial killing and membrane trafficking.
