Making life a bit easier... - pE131

doi:10.1038/35078590

Full Text - Making life a bit easier... | PDF (56 KB) - Making life a bit easier...

Round-trip ticket: recycling to the plasma membrane requires RME-1 - ppE133 - E135

Beverly Wendland

doi:10.1038/35078592

The endosomal system includes distinct endocytic compartments where decisions are made that determine the destinations of extracellular and plasma membrane materials that have been internalized. A new family of proteins has been found that governs the exit of material from one of these endocytic organelles, the endosomal recycling compartment (ERC).

Full Text - Round-trip ticket: recycling to the plasma membrane requires RME-1 | PDF (1,255 KB) - Round-trip ticket: recycling to the plasma membrane requires RME-1

Passage through the nuclear pore - pE135

Barbara Marte

doi:10.1038/35078596

Full Text - Passage through the nuclear pore | PDF (1,084 KB) - Passage through the nuclear pore

Pin-pointing MAPK signalling - ppE136 - E137

Matthew Freeman

doi:10.1038/35078599

In the Drosophila egg, during signalling through the epidermal growth factor (EGF) receptor, a conformational switch, which is dependent on mitogen-activated protein kinase (MAPK) leads to the Cf2 transcriptio-nal repressor being targeted for proteolysis. Recent work shows that this switch is catalysed by the Drosophila homologue of Pin1, a peptidyl-prolyl isomerase.

Full Text - Pin-pointing MAPK signalling | PDF (200 KB) - Pin-pointing MAPK signalling

Building from the bottom up - ppE138 - E139

Catherine E. Krull & Robb Krumlauf

doi:10.1038/35078603

Time-lapse analyses of normal cellular behaviours and signalling by fibroblast growth factor (FGF) provide new insights into the cell motions and molecules that form the posterior nervous system.

Full Text - Building from the bottom up | PDF (162 KB) - Building from the bottom up

Membrane–cytoskeletal dynamics in a new dimension - ppE140 - E142

John E. Heuser & Julie G. Donaldson

doi:10.1038/35078606

Abstract - | Full Text - Membrane–cytoskeletal dynamics in a new dimension | PDF (180 KB) - Membrane–cytoskeletal dynamics in a new dimension

The Goldilocks tale of cytokines: Getting it right - pE143

David Hockenberry reviews Novel Cytokine Inhibitors by

doi:10.1038/35078609

Full Text - The Goldilocks tale of cytokines: Getting it right | PDF (126 KB) - The Goldilocks tale of cytokines: Getting it right

Unravelling transcription - pE144

Chris Murawsky & Andrew Travers review Gene Transcription-Mechanisms and Control by

doi:10.1038/35078612

Full Text - Unravelling transcription | PDF (126 KB) - Unravelling transcription

From fixed to FRAP: measuring protein mobility and activity in living cells - ppE145 - E147

Eric A.J. Reits & Jacques J. Neefjes

doi:10.1038/35078615

Abstract - | Full Text - From fixed to FRAP: measuring protein mobility and activity in living cells | PDF (257 KB) - From fixed to FRAP: measuring protein mobility and activity in living cells

Dynamics of the COPII coat with GTP and stable analogues - pp531 - 537

Bruno Antonny, David Madden, Susan Hamamoto, Lelio Orci & Randy Schekman

doi:10.1038/35078500

Abstract - | Full Text - Dynamics of the COPII coat with GTP and stable analogues | PDF (909 KB) - Dynamics of the COPII coat with GTP and stable analogues

Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis - pp538 - 543

Tien Hsu, Daniel McRackan, Timothy S. Vincent & H. Gert de Couet

doi:10.1038/35078508

Abstract - | Full Text - Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis | PDF (621 KB) - Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis

See also: News and Views by Freeman

Actin dynamics at pointed ends regulates thin filament length in striated muscle - pp544 - 551

Ryan Littlefield, Angels Almenar-Queralt & Velia M. Fowler

doi:10.1038/35078517

Abstract - | Full Text - Actin dynamics at pointed ends regulates thin filament length in striated muscle | PDF (1,210 KB) - Actin dynamics at pointed ends regulates thin filament length in striated muscle | Supplementary information

Apaf-1 is a transcriptional target for E2F and p53 - pp552 - 558

M. Cristina Moroni, Emma S. Hickman, Eros Lazzerini Denchi, Greta Caprara, Elena Colli, Francesco Cecconi, Heiko Müller & Kristian Helin

doi:10.1038/35078527

Abstract - | Full Text - Apaf-1 is a transcriptional target for E2F and p53 | PDF (1,726 KB) - Apaf-1 is a transcriptional target for E2F and p53 | Supplementary information

FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression - pp559 - 566

Luc Mathis, Paul M. Kulesa & Scott E. Fraser

doi:10.1038/35078535

Abstract - | Full Text - FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression | PDF (1,266 KB) - FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression | Supplementary information

See also: News and Views by Krull & Krumlauf

Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells - pp567 - 572

Sharron X. Lin, Barth Grant, David Hirsh & Frederick R. Maxfield

doi:10.1038/35078543

Abstract - | Full Text - Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells | PDF (502 KB) - Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

See also: News and Views by Wendland

Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling - pp573 - 579

Barth Grant, Yinhua Zhang, Marie-Christine Paupard, Sharron X. Lin, David H. Hall & David Hirsh

doi:10.1038/35078549

Abstract - | Full Text - Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling | PDF (1,750 KB) - Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling

See also: News and Views by Wendland

Regulation of c-myc expression by PDGF through Rho GTPases - pp580 - 586

Mario Chiariello, Maria Julia Marinissen & J. Silvio Gutkind

doi:10.1038/35078555

Abstract - | Full Text - Regulation of c-myc expression by PDGF through Rho GTPases | PDF (345 KB) - Regulation of c-myc expression by PDGF through Rho GTPases

TGF- induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation - pp587 - 595

Shirin Bonni, Hong-Rui Wang, Carrie G. Causing, Peter Kavsak, Shannon L. Stroschein, Kunxin Luo & Jeffrey L. Wrana

doi:10.1038/35078562

Abstract - | Full Text - TGF- induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation | PDF (450 KB) - TGF- induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila - pp596 - 601

Mathieu Miron, Javier Verdú, Pascal E.D. Lachance, Morris J. Birnbaum, Paul F. Lasko & Nahum Sonenberg

doi:10.1038/35078571

Abstract - | Full Text - The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila | PDF (1,980 KB) - The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

Expression of - and -globin genes occurs within different nuclear domains in haemopoietic cells - pp602 - 606

Karen E. Brown, Shannon Amoils, Jacqueline M. Horn, Veronica J. Buckle, Douglas R. Higgs, Matthias Merkenschlager & Amanda G. Fisher

doi:10.1038/35078577

Abstract - | Full Text - Expression of - and -globin genes occurs within different nuclear domains in haemopoietic cells | PDF (234 KB) - Expression of - and -globin genes occurs within different nuclear domains in haemopoietic cells | Supplementary information

Direct, high-resolution measurement of furrow stiffening during division of adherent cells - pp607 - 610

Rainer Matzke, Ken Jacobson & Manfred Radmacher

doi:10.1038/35078583

Abstract - | Full Text - Direct, high-resolution measurement of furrow stiffening during division of adherent cells | PDF (354 KB) - Direct, high-resolution measurement of furrow stiffening during division of adherent cells