1. Matthew Freeman is in the MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
   e-mail: MF1@mrc-lmb.cam.ac.uk

Abstract

In the Drosophila egg, during signalling through the epidermal growth factor (EGF) receptor, a conformational switch, which is dependent on mitogen-activated protein kinase (MAPK) leads to the Cf2 transcriptio-nal repressor being targeted for proteolysis. Recent work shows that this switch is catalysed by the Drosophila homologue of Pin1, a peptidyl-prolyl isomerase.

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