Article abstract
Nature Cell Biology 3, 538 - 543 (2001)
Published online: 2 May 2001 | doi:10.1038/35078508
Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis
Tien Hsu1,2, Daniel McRackan1, Timothy S. Vincent3 & H. Gert de Couet4
Abstract
The mammalian cis–trans prolyl isomerase Pin1 and its yeast orthologue Ess1/Ptf1 have been implicated in cell cycle control but a correlation between biochemical and physiological functions has not been established conclusively. Pin1 targets the proline residue carboxy-terminal to the phosphorylated threonine or serine residue, which constitutes part of the phosphorylated mitogen-activated protein kinase (MAPK) site PXpT/SP. Here we show that the Drosophila Pin1 homologue, the Dodo protein, is involved in dorsoventral patterning of the follicular epithelium in the egg chamber. Its function is to facilitate the degradation of transcription factor CF2, which requires, a priori, activated epidermal growth factor receptor–MAPK signalling.
- Laboratory of Cancer Genomics, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina 29425, U.S.A.
- Department of Cell Biology and Anatomy, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina 29425, USA
- Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
- Department of Zoology, University of Hawai'i, Honolulu, Hawai'i, USA
Correspondence to: Tien Hsu1,2 e-mail: hsut@musc.edu
