Controversy and debate: the nature of science - pE103

doi:10.1038/35074611

Full Text - Controversy and debate: the nature of science | PDF (65 KB) - Controversy and debate: the nature of science

Presenilin and the UPR - pE104

K. Imaizumi, T. Katayama & M. Tohyama

doi:10.1038/35074613

Full Text - Presenilin and the UPR | PDF (132 KB) - Presenilin and the UPR

More light on Decoding Darkness - pE104

E. Koo

doi:10.1038/35074616

Full Text - More light on Decoding Darkness | PDF (132 KB) - More light on Decoding Darkness

Centrosomes as command centres for cellular control - ppE105 - E108

Stephen J. Doxsey

doi:10.1038/35074618

For almost a century, our understanding of the tiny structure at the centre of the cell called the centrosome was limited to its ability to organize mitotic spindles and other microtubule arrays. However, recent studies have indicated new roles for centrosomes in cytokinesis and cell-cycle progression.

Full Text - Centrosomes as command centres for cellular control | PDF (1,259 KB) - Centrosomes as command centres for cellular control

G-protein activation live - pE107

Valerie Depraetere

doi:10.1038/35074622

Full Text - G-protein activation live | PDF (100 KB) - G-protein activation live

Caveolae on the move - ppE108 - E110

Suzanne R. Pfeffer

doi:10.1038/35074625

Caveolae deliver simian virus 40 (SV40) to a new compartment called a caveosome, where the virus is sorted for transport to the smooth endoplasmic reticulum (ER). This pathway bypasses other endocytic organelles, and early steps may be shared by lipid rafts and certain glycosylphosphatidylinositol (GPI)-linked proteins.

Full Text - Caveolae on the move | PDF (140 KB) - Caveolae on the move

Another Notch in neurogenesis - pE109

Sarah Greaves

doi:10.1038/35074628

Full Text - Another Notch in neurogenesis | PDF (114 KB) - Another Notch in neurogenesis

Getting a grip: new insights for cell adhesion and traction - ppE110 - E112

Douglas A. Lauffenburger & Alan Wells

doi:10.1038/35074631

A crucial aspect of cell function in tissues is the biophysical interactions of the cell with the surrounding extracellular matrix. A fascinating report in this issue offers a major advance in the techniques available for investigating how the transmission of cell-generated forces to an underlying substratum is regulated. Application of this approach should provide key insights into such force regulation during cell migration and matrix contraction.

Full Text - Getting a grip: new insights for cell adhesion and traction | PDF (142 KB) - Getting a grip: new insights for cell adhesion and traction

Integrating Myc and TGF- signalling in cell-cycle control - ppE112 - E113

Bruno Amati

doi:10.1038/35074634

Expression of the cell cycle inhibitor p15^INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor- (TGF-). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF--activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

Full Text - Integrating Myc and TGF- signalling in cell-cycle control | PDF (95 KB) - Integrating Myc and TGF- signalling in cell-cycle control

Vitamins at the heart of heart disease? - pE115

Kelly L. Krass & Aldons J. Lusis review Atherosclerosis: Gene Expression, Cell Interactions and Oxidation by

doi:10.1038/35074637

Full Text - Vitamins at the heart of heart disease? | PDF (92 KB) - Vitamins at the heart of heart disease?

Getting from here to there - pE116

Lucy Erin O'Brien & Keith Mostov review Essays in Biochemistry: Molecular Trafficking by

doi:10.1038/35074640

Full Text - Getting from here to there | PDF (96 KB) - Getting from here to there

Mechanisms of epithelial fusion and repair - ppE117 - E123

Antonio Jacinto, Alfonso Martinez-Arias & Paul Martin

doi:10.1038/35074643

Abstract - | Full Text - Mechanisms of epithelial fusion and repair | PDF (594 KB) - Mechanisms of epithelial fusion and repair

Coping with the inevitable: how cells repair a torn surface membrane - ppE124 - E129

Paul L. McNeil & Mark Terasaki

doi:10.1038/35074652

Abstract - | Full Text - Coping with the inevitable: how cells repair a torn surface membrane | PDF (409 KB) - Coping with the inevitable: how cells repair a torn surface membrane

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain - pp439 - 444

Riyan Chen, Oekyung Kim, Ming Li, Xinsheng Xiong, Jun-Lin Guan, Hsing-Jien Kung, Hegang Chen, Yoji Shimizu & Yun Qiu

doi:10.1038/35074500

Abstract - | Full Text - Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain | PDF (415 KB) - Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

Stabilization of p53 by p14^ARF without relocation of MDM2 to the nucleolus - pp445 - 452

Susana Llanos, Paula A. Clark, Janice Rowe & Gordon Peters

doi:10.1038/35074506

Abstract - | Full Text - Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus | PDF (2,510 KB) - Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 - pp453 - 459

Takeshi Harada, Takaya Morooka, Satoshi Ogawa & Eisuke Nishida

doi:10.1038/35074516

Abstract - | Full Text - ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 | PDF (1,393 KB) - ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras - pp460 - 465

Nicholas A. Cacalano, David Sanden & James A. Johnston

doi:10.1038/35074525

Abstract - | Full Text - Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras | PDF (382 KB) - Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates - pp466 - 472

Nathalie Q. Balaban, Ulrich S. Schwarz, Daniel Riveline, Polina Goichberg, Gila Tzur, Ilana Sabanay, Diana Mahalu, Sam Safran, Alexander Bershadsky, Lia Addadi & Benjamin Geiger

doi:10.1038/35074532

Abstract - | Full Text - Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates | PDF (791 KB) - Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates | Supplementary information

See also: News and Views by Lauffenburger & Wells

Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER - pp473 - 483

Lucas Pelkmans, Jürgen Kartenbeck & Ari Helenius

doi:10.1038/35074539

Abstract - | Full Text - Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER | PDF (4,252 KB) - Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER | Supplementary information

See also: News and Views by Pfeffer

WIP regulates N-WASP-mediated actin polymerization and filopodium formation - pp484 - 491

Narcisa Martinez-Quiles, Rajat Rohatgi, Inés M. Antón, Miguel Medina, Stephen P. Saville, Hiroaki Miki, Hideki Yamaguchi, Tadaomi Takenawa, John H. Hartwig, Raif S. Geha & Narayanaswamy Ramesh

doi:10.1038/35074551

Abstract - | Full Text - WIP regulates N-WASP-mediated actin polymerization and filopodium formation | PDF (2,525 KB) - WIP regulates N-WASP-mediated actin polymerization and filopodium formation

Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein - pp492 - 498

Jason C. Bermak, Ming Li, Clayton Bullock & Qun-Yong Zhou

doi:10.1038/35074561

Abstract - | Full Text - Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein | PDF (2,662 KB) - Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein

Trp2 regulates entry of Ca²⁺ into mouse sperm triggered by egg ZP3 - pp499 - 502

Melissa K. Jungnickel, Hector Marrero, Lutz Birnbaumer, José R. Lémos & Harvey M. Florman

doi:10.1038/35074570

Abstract - | Full Text - Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3 | PDF (263 KB) - Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3

A 'hot-spot' mutation alters the mechanical properties of keratin filament networks - pp503 - 506

Linglei Ma, Soichiro Yamada, Denis Wirtz & Pierre A. Coulombe

doi:10.1038/35074576

Abstract - | Full Text - A 'hot-spot' mutation alters the mechanical properties of keratin filament networks | PDF (895 KB) - A 'hot-spot' mutation alters the mechanical properties of keratin filament networks

New protease inhibitors prevent -secretase-mediated production of A40/42 without affecting Notch cleavage - pp507 - 511

Agnès Petit, Frédéric Bihel, Cristine Alvès da Costa, Olivier Pourquié, Frédéric Checler & Jean-Louis Kraus

doi:10.1038/35074581

Abstract - | Full Text - New protease inhibitors prevent -secretase-mediated production of A40/42 without affecting Notch cleavage | PDF (265 KB) - New protease inhibitors prevent -secretase-mediated production of A40/42 without affecting Notch cleavage

PDGF-D is a specific, protease-activated ligand for the PDGF -receptor - pp512 - 516

Erika Bergsten, Marko Uutela, Xuri Li, Kristian Pietras, Arne Östman, Carl-Henrik Heldin, Kari Alitalo & Ulf Eriksson

doi:10.1038/35074588

Abstract - | Full Text - PDGF-D is a specific, protease-activated ligand for the PDGF -receptor | PDF (469 KB) - PDGF-D is a specific, protease-activated ligand for the PDGF -receptor

PDGF-D, a new protease-activated growth factor - pp517 - 521

William J. LaRochelle, Michael Jeffers, William F. McDonald, Rajeev A. Chillakuru, Neill A. Giese, Nathalie A. Lokker, Carol Sullivan, Ferenc L. Boldog, Meijia Yang, Corine Vernet, Catherine E. Burgess, Elma Fernandes, Lisa L. Deegler, Beth Rittman, Juliette Shimkets, Richard A. Shimkets, Jonathan M. Rothberg & Henri S. Lichenstein

doi:10.1038/35074593

Abstract - | Full Text - PDGF-D, a new protease-activated growth factor | PDF (563 KB) - PDGF-D, a new protease-activated growth factor

Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation - pp522 - 526

Pascal Bernard, Jean-François Maure & Jean-Paul Javerzat

doi:10.1038/35074598

Abstract - | Full Text - Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation | PDF (892 KB) - Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway - pp527 - 530

Hui Miao, Bih-Rong Wei, Donna M. Peehl, Qing Li, Terry Alexandrou, Jeffrey R. Schelling, Johng S. Rhim, John R. Sedor, Elisabeth Burnett & Bingcheng Wang

doi:10.1038/35074604

Abstract - | Full Text - Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway | PDF (304 KB) - Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

Erratum - p530

doi:10.1038/35074609

Full Text - Erratum | PDF (52 KB) - Erratum