Table of contents
May 2001, Volume 3 No 5 ppE103-530
About the coverEditorial
Controversy and debate: the nature of science - pE103
doi:10.1038/35074611
Full Text - Controversy and debate: the nature of science | PDF (65 KB) - Controversy and debate: the nature of science
Letters to Editor
Presenilin and the UPR - pE104
K. Imaizumi, T. Katayama & M. Tohyama
doi:10.1038/35074613
Full Text - Presenilin and the UPR | PDF (132 KB) - Presenilin and the UPR
More light on Decoding Darkness - pE104
E. Koo
doi:10.1038/35074616
Full Text - More light on Decoding Darkness | PDF (132 KB) - More light on Decoding Darkness
News and Views
Centrosomes as command centres for cellular control - ppE105 - E108
Stephen J. Doxsey
doi:10.1038/35074618
For almost a century, our understanding of the tiny structure at the centre of the cell called the centrosome was limited to its ability to organize mitotic spindles and other microtubule arrays. However, recent studies have indicated new roles for centrosomes in cytokinesis and cell-cycle progression.
Full Text - Centrosomes as command centres for cellular control | PDF (1,259 KB) - Centrosomes as command centres for cellular control
G-protein activation live - pE107
Valerie Depraetere
doi:10.1038/35074622
Full Text - G-protein activation live | PDF (100 KB) - G-protein activation live
Caveolae on the move - ppE108 - E110
Suzanne R. Pfeffer
doi:10.1038/35074625
Caveolae deliver simian virus 40 (SV40) to a new compartment called a caveosome, where the virus is sorted for transport to the smooth endoplasmic reticulum (ER). This pathway bypasses other endocytic organelles, and early steps may be shared by lipid rafts and certain glycosylphosphatidylinositol (GPI)-linked proteins.
Full Text - Caveolae on the move | PDF (140 KB) - Caveolae on the move
Another Notch in neurogenesis - pE109
Sarah Greaves
doi:10.1038/35074628
Full Text - Another Notch in neurogenesis | PDF (114 KB) - Another Notch in neurogenesis
Getting a grip: new insights for cell adhesion and traction - ppE110 - E112
Douglas A. Lauffenburger & Alan Wells
doi:10.1038/35074631
A crucial aspect of cell function in tissues is the biophysical interactions of the cell with the surrounding extracellular matrix. A fascinating report in this issue offers a major advance in the techniques available for investigating how the transmission of cell-generated forces to an underlying substratum is regulated. Application of this approach should provide key insights into such force regulation during cell migration and matrix contraction.
Full Text - Getting a grip: new insights for cell adhesion and traction | PDF (142 KB) - Getting a grip: new insights for cell adhesion and traction
Integrating Myc and TGF-
signalling in cell-cycle control - ppE112 - E113
Bruno Amati
doi:10.1038/35074634
Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-
(TGF-
). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-
-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.
Full Text - Integrating Myc and TGF-
signalling in cell-cycle control | PDF (95 KB) - Integrating Myc and TGF-
signalling in cell-cycle control
Book Reviews
Vitamins at the heart of heart disease? - pE115
Kelly L. Krass & Aldons J. Lusis review Atherosclerosis: Gene Expression, Cell Interactions and Oxidation by
doi:10.1038/35074637
Full Text - Vitamins at the heart of heart disease? | PDF (92 KB) - Vitamins at the heart of heart disease?
Getting from here to there - pE116
Lucy Erin O'Brien & Keith Mostov review Essays in Biochemistry: Molecular Trafficking by
doi:10.1038/35074640
Full Text - Getting from here to there | PDF (96 KB) - Getting from here to there
Reviews
Mechanisms of epithelial fusion and repair - ppE117 - E123
Antonio Jacinto, Alfonso Martinez-Arias & Paul Martin
doi:10.1038/35074643
Abstract - | Full Text - Mechanisms of epithelial fusion and repair | PDF (594 KB) - Mechanisms of epithelial fusion and repair
Coping with the inevitable: how cells repair a torn surface membrane - ppE124 - E129
Paul L. McNeil & Mark Terasaki
doi:10.1038/35074652
Abstract - | Full Text - Coping with the inevitable: how cells repair a torn surface membrane | PDF (409 KB) - Coping with the inevitable: how cells repair a torn surface membrane
Articles
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain - pp439 - 444
Riyan Chen, Oekyung Kim, Ming Li, Xinsheng Xiong, Jun-Lin Guan, Hsing-Jien Kung, Hegang Chen, Yoji Shimizu & Yun Qiu
doi:10.1038/35074500
Abstract - | Full Text - Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain | PDF (415 KB) - Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus - pp445 - 452
Susana Llanos, Paula A. Clark, Janice Rowe & Gordon Peters
doi:10.1038/35074506
Abstract - | Full Text - Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus | PDF (2,510 KB) - Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 - pp453 - 459
Takeshi Harada, Takaya Morooka, Satoshi Ogawa & Eisuke Nishida
doi:10.1038/35074516
Abstract - | Full Text - ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 | PDF (1,393 KB) - ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras - pp460 - 465
Nicholas A. Cacalano, David Sanden & James A. Johnston
doi:10.1038/35074525
Abstract - | Full Text - Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras | PDF (382 KB) - Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates - pp466 - 472
Nathalie Q. Balaban, Ulrich S. Schwarz, Daniel Riveline, Polina Goichberg, Gila Tzur, Ilana Sabanay, Diana Mahalu, Sam Safran, Alexander Bershadsky, Lia Addadi & Benjamin Geiger
doi:10.1038/35074532
Abstract - | Full Text - Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates | PDF (791 KB) - Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates | Supplementary information
See also: News and Views by Lauffenburger & Wells
Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER - pp473 - 483
Lucas Pelkmans, Jürgen Kartenbeck & Ari Helenius
doi:10.1038/35074539
Abstract - | Full Text - Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER | PDF (4,252 KB) - Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER | Supplementary information
See also: News and Views by Pfeffer
WIP regulates N-WASP-mediated actin polymerization and filopodium formation - pp484 - 491
Narcisa Martinez-Quiles, Rajat Rohatgi, Inés M. Antón, Miguel Medina, Stephen P. Saville, Hiroaki Miki, Hideki Yamaguchi, Tadaomi Takenawa, John H. Hartwig, Raif S. Geha & Narayanaswamy Ramesh
doi:10.1038/35074551
Abstract - | Full Text - WIP regulates N-WASP-mediated actin polymerization and filopodium formation | PDF (2,525 KB) - WIP regulates N-WASP-mediated actin polymerization and filopodium formation
Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein - pp492 - 498
Jason C. Bermak, Ming Li, Clayton Bullock & Qun-Yong Zhou
doi:10.1038/35074561
Abstract - | Full Text - Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein | PDF (2,662 KB) - Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein
Brief Communications
Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3 - pp499 - 502
Melissa K. Jungnickel, Hector Marrero, Lutz Birnbaumer, José R. Lémos & Harvey M. Florman
doi:10.1038/35074570
Abstract - | Full Text - Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3 | PDF (263 KB) - Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3
A 'hot-spot' mutation alters the mechanical properties of keratin filament networks - pp503 - 506
Linglei Ma, Soichiro Yamada, Denis Wirtz & Pierre A. Coulombe
doi:10.1038/35074576
Abstract - | Full Text - A 'hot-spot' mutation alters the mechanical properties of keratin filament networks | PDF (895 KB) - A 'hot-spot' mutation alters the mechanical properties of keratin filament networks
New protease inhibitors prevent
-secretase-mediated production of A
40/42 without affecting Notch cleavage - pp507 - 511
Agnès Petit, Frédéric Bihel, Cristine Alvès da Costa, Olivier Pourquié, Frédéric Checler & Jean-Louis Kraus
doi:10.1038/35074581
Abstract - | Full Text - New protease inhibitors prevent
-secretase-mediated production of A
40/42 without affecting Notch cleavage | PDF (265 KB) - New protease inhibitors prevent
-secretase-mediated production of A
40/42 without affecting Notch cleavage
PDGF-D is a specific, protease-activated ligand for the PDGF
-receptor - pp512 - 516
Erika Bergsten, Marko Uutela, Xuri Li, Kristian Pietras, Arne Östman, Carl-Henrik Heldin, Kari Alitalo & Ulf Eriksson
doi:10.1038/35074588
Abstract - | Full Text - PDGF-D is a specific, protease-activated ligand for the PDGF
-receptor | PDF (469 KB) - PDGF-D is a specific, protease-activated ligand for the PDGF
-receptor
PDGF-D, a new protease-activated growth factor - pp517 - 521
William J. LaRochelle, Michael Jeffers, William F. McDonald, Rajeev A. Chillakuru, Neill A. Giese, Nathalie A. Lokker, Carol Sullivan, Ferenc L. Boldog, Meijia Yang, Corine Vernet, Catherine E. Burgess, Elma Fernandes, Lisa L. Deegler, Beth Rittman, Juliette Shimkets, Richard A. Shimkets, Jonathan M. Rothberg & Henri S. Lichenstein
doi:10.1038/35074593
Abstract - | Full Text - PDGF-D, a new protease-activated growth factor | PDF (563 KB) - PDGF-D, a new protease-activated growth factor
Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation - pp522 - 526
Pascal Bernard, Jean-François Maure & Jean-Paul Javerzat
doi:10.1038/35074598
Abstract - | Full Text - Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation | PDF (892 KB) - Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway - pp527 - 530
Hui Miao, Bih-Rong Wei, Donna M. Peehl, Qing Li, Terry Alexandrou, Jeffrey R. Schelling, Johng S. Rhim, John R. Sedor, Elisabeth Burnett & Bingcheng Wang
doi:10.1038/35074604
Abstract - | Full Text - Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway | PDF (304 KB) - Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway


