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Nature Cell Biology 3, E105–E108 (1 May 2001) | doi:10.1038/35074618

Centrosomes as command centres for cellular control

Stephen J. Doxsey

The centrosome is positioned in the centre of interphase cells at the focus of a radial array of microtubules. Microtubules are polymers composed of α- and β-tubulin subunits, and their growth is initiated in the peripheral region of the centrosome (the pericentriolar matrix) by a complex containing a related protein called γ-tubulin.