Breaking the language barrier - pE89

doi:10.1038/35070145

Abstract - | Full Text - Breaking the language barrier | PDF (59 KB) - Breaking the language barrier

Problems with LAP nomenclature - pE90

Katherine L. Wilson, Ricardo Benavente, Brian Burke, Robert Craigie, Roland Foisner, Kazuhiro Furukawa, Larry Gerace, Robert D. Goldman, Yosef Gruenbaum, Crafford Harris, Christopher J. Hutchison, Georg Krohne, Glenn E. Morris, Henning Otto, Amos J. Simon & Howard J. Worman

doi:10.1038/35070147

Full Text - Problems with LAP nomenclature | PDF (77 KB) - Problems with LAP nomenclature

Response to "Problems with LAP nomenclature" - pE90

David Bilder, Daniel Birnbaum, Jean-Paul Borg, Jon Huibregtse, Mary Kennedy, Michel Labouesse, Bernard Mechler & Norbert Perrimon

doi:10.1038/35070149

Full Text - Response to "Problems with LAP nomenclature" | PDF (77 KB) - Response to "Problems with LAP nomenclature"

Apoptosis: caspases orchestrate the ROCK `n' bleb - ppE91 - E92

Yann Leverrier & Anne J. Ridley

doi:10.1038/35070151

Although membrane blebbing is a characteristic morphological change associated with apoptosis, little is known about the mechanisms underlying this process. New research has identified the Rho GTPase target ROCK-I as being cleaved by caspases during apoptosis. ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I is constitutively active and is responsible for bleb formation in apoptotic cells.

Full Text - Apoptosis: caspases orchestrate the ROCK `n' bleb | PDF (224 KB) - Apoptosis: caspases orchestrate the ROCK `n' bleb

Stressing endocytosis - pE92

Barbara Marte

doi:10.1038/35070154

Full Text - Stressing endocytosis | PDF (80 KB) - Stressing endocytosis

The survival motor neurons protein uses its ZPR for nuclear localization - ppE93 - E94

A. Gregory Matera & Michael D. Hebert

doi:10.1038/35070157

Spinal muscular atrophy is caused by mutations in the survival motor neurons gene, SMN1. The SMN protein localizes to both the cytoplasm and the nuclear bodies. One hallmark of spinal muscular atrophy is the failure of SMN to localize within these nuclear bodies. A recent study has identified a protein called ZPR1 that is required for nuclear translocation of SMN.

Full Text - The survival motor neurons protein uses its ZPR for nuclear localization | PDF (354 KB) - The survival motor neurons protein uses its ZPR for nuclear localization

p27 destruction: Cks1 pulls the trigger - ppE95 - E97

Jiri Bartek & Jiri Lukas

doi:10.1038/35070160

Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27^Kip1. This process is essential for DNA replication and is aberrantly enhanced in cancer. Surprisingly, new work indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.

Full Text - p27 destruction: Cks1 pulls the trigger | PDF (268 KB) - p27 destruction: Cks1 pulls the trigger

Stung by WASP - pE95

Angela Eggleston

doi:10.1038/35070164

Full Text - Stung by WASP | PDF (98 KB) - Stung by WASP

Obituary Arnold Greenberg - pE98

Pierre Golstein

doi:10.1038/35070167

Full Text - Obituary Arnold Greenberg | PDF (105 KB) - Obituary Arnold Greenberg

Puzzling thoughts - pE99

Matthew J. O'Connell reviews Archimedes' Bathtub: The Art and Logic of Breakthrough Thinking by

doi:10.1038/35070170

Full Text - Puzzling thoughts | PDF (104 KB) - Puzzling thoughts

Functional genomics touches base - pE100

Philippe Vaglio & Marc Vidal review Genomics and Proteomics: Functional and Computational Aspects by

doi:10.1038/35070137

Full Text - Functional genomics touches base | PDF (98 KB) - Functional genomics touches base

Functional genomics touches base - pE100

Sarah Greaves reviews Proteomics by

doi:10.1038/35070140

Full Text - Functional genomics touches base | PDF (98 KB) - Functional genomics touches base

The Boston Alzheimer connection - pE101

Edward Koo reviews Decoding Darkness: the Search for the Genetic Cause of Alzheimer's disease by

doi:10.1038/35070142

Full Text - The Boston Alzheimer connection | PDF (107 KB) - The Boston Alzheimer connection

Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex - pp331 - 338

Milan G. Chheda, Uri Ashery, Pratima Thakur, Jens Rettig & Zu-Hang Sheng

doi:10.1038/35070000

Abstract - | Full Text - Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex | PDF (527 KB) - Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I - pp339 - 345

Mathew L. Coleman, Erik A. Sahai, Margaret Yeo, Marta Bosch, Ann Dewar & Michael F. Olson

doi:10.1038/35070009

Abstract - | Full Text - Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I | PDF (1,987 KB) - Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I | Supplementary information

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing - pp346 - 352

Michaël Sebbagh, Claire Renvoizé, Jocelyne Hamelin, Nicole Riché, Jacques Bertoglio & Jacqueline Bréard

doi:10.1038/35070019

Abstract - | Full Text - Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing | PDF (546 KB) - Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

Spatial regulation of the exocyst complex by Rho1 GTPase - pp353 - 360

Wei Guo, Fuyuhiko Tamanoi & Peter Novick

doi:10.1038/35070029

Abstract - | Full Text - Spatial regulation of the exocyst complex by Rho1 GTPase | PDF (1,873 KB) - Spatial regulation of the exocyst complex by Rho1 GTPase

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation - pp361 - 367

Madeleine R. Brouns, Stephen F. Matheson & Jeffrey Settleman

doi:10.1038/35070042

Abstract - | Full Text - p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation | PDF (1,027 KB) - p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity - pp368 - 375

Ian A. Prior, Angus Harding, Jun Yan, Judith Sluimer, Robert G. Parton & John F. Hancock

doi:10.1038/35070050

Abstract - | Full Text - GTP-dependent segregation of H-ras from lipid rafts is required for biological activity | PDF (524 KB) - GTP-dependent segregation of H-ras from lipid rafts is required for biological activity | Supplementary information

Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein - pp376 - 383

Laxman Gangwani, Monique Mikrut, Steven Theroux, Manoj Sharma & Roger J. Davis

doi:10.1038/35070059

Abstract - | Full Text - Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein | PDF (787 KB) - Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein

Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly - pp384 - 391

Jae Hong Seol, Anna Shevchenko, Andrej Shevchenko & Raymond J. Deshaies

doi:10.1038/35070067

Abstract - | Full Text - Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly | PDF (635 KB) - Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly

Repression of p15^INK4b expression by Myc through association with Miz-1 - pp392 - 399

Peter Staller, Karen Peukert, Astrid Kiermaier, Joan Seoane, Jiri Lukas, Holger Karsunky, Tarik Möröy, Jiri Bartek, Joan Massagué, Frank Hänel & Martin Eilers

doi:10.1038/35070076

Abstract - | Full Text - Repression of p15INK4b expression by Myc through association with Miz-1 | PDF (733 KB) - Repression of p15INK4b expression by Myc through association with Miz-1

TGF influences Myc, Miz-1 and Smad to control the CDK inhibitor p15^INK4b - pp400 - 408

Joan Seoane, Celio Pouponnot, Peter Staller, Manuela Schader, Martin Eilers & Joan Massagué

doi:10.1038/35070086

Abstract - | Full Text - TGF influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b | PDF (542 KB) - TGF influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b | Supplementary information

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-B - pp409 - 416

Rajani Ravi, Gauri. C. Bedi, Laura W. Engstrom, Qinwen Zeng, Bijoyesh Mookerjee, Céline Gélinas, Ephraim J. Fuchs & Atul Bedi

doi:10.1038/35070096

Abstract - | Full Text - Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-B | PDF (1,975 KB) - Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-B

A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint - pp417 - 420

Jacob C. Harrison, Elaine S.G. Bardes, Yoshikazu Ohya & Daniel J. Lew

doi:10.1038/35070104

Abstract - | Full Text - A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint | PDF (264 KB) - A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint | Supplementary information

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes - pp421 - 424

Maria do Carmo Avides, Alvaro Tavares & David M. Glover

doi:10.1038/35070110

Abstract - | Full Text - Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes | PDF (908 KB) - Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes

Substeps within the 8-nm step of the ATPase cycle of single kinesin molecules - pp425 - 428

Masayoshi Nishiyama, Etsuko Muto, Yuichi Inoue, Toshio Yanagida & Hideo Higuchi

doi:10.1038/35070116

Abstract - | Full Text - Substeps within the 8-nm step of the ATPase cycle of single kinesin molecules | PDF (1,101 KB) - Substeps within the 8-nm step of the ATPase cycle of single kinesin molecules

A role for the Adenomatous Polyposis Coli protein in chromosome segregation - pp429 - 432

Kenneth B. Kaplan, Aurora A. Burds, Jason R. Swedlow, Songül S. Bekir, Peter K. Sorger & Inke S. Näthke

doi:10.1038/35070123

Abstract - | Full Text - A role for the Adenomatous Polyposis Coli protein in chromosome segregation | PDF (294 KB) - A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Mutations in the APC tumour suppressor gene cause chromosomal instability - pp433 - 438

Riccardo Fodde, Jeroen Kuipers, Carla Rosenberg, Ron Smits, Menno Kielman, Claudia Gaspar, Johan H. van Es, Cor Breukel, Joop Wiegant, Rachel H. Giles & Hans Clevers

doi:10.1038/35070129

Abstract - | Full Text - Mutations in the APC tumour suppressor gene cause chromosomal instability | PDF (795 KB) - Mutations in the APC tumour suppressor gene cause chromosomal instability | Supplementary information

Erratum - p438

doi:10.1038/35070173

Full Text - Erratum | PDF (48 KB) - Erratum