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Nature Cell Biology 3, E95–E97 (1 April 2001) | doi:10.1038/35070160
p27 destruction: Cks1 pulls the trigger
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Abstract
The cell's ability to self-reproduce is a fundamental feature of life, essential for species continuation and embryonic development, as well as tissue renewal in adult organisms, including humans. Cellular self-reproduction reflects the workings of the cell division cycle machinery, whose two major driving forces, the activities of cyclin-dependent kinases (CDKs) and ubiquitin-mediated, proteasome-dependent proteolysis, are carefully orchestrated at multiple levels.
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