Jiri Bartek and Jiri Lukas are in the Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark
bartek@biobase.dk
Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27Kip1. This process is essential for DNA replication and is aberrantly enhanced in cancer. Surprisingly, new work indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.
