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Nature Cell Biology 3, E71 - E73 (2001)
doi:10.1038/35060148
Akt takes centre stage in cell-cycle deregulation
Wafik S. El-Deiry1
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Wafik S. El-Deiry is in the Laboratory of Molecular
Oncology and Cell Cycle Regulation, Departments of Medicine, Genetics and
Pharmacology, Howard Hughes Medical Institute, University of Pennsylvania
School of Medicine, 415 Curie Boulevard, Philadelphia
, Pennsylvania 19104, USA.
e-mail: wafik@mail.med.upenn.edu
Abstract
The universal cell-cycle inhibitor p21Cip1/WAF1 is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer.
