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Brief Communication
Nature Cell Biology 3, 198–203 (1 February 2001) | doi:10.1038/35055110
Escape from premature senescence is not sufficient for oncogenic transformation by Ras
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Abstract
Resistance of primary cells to transformation by oncogenic Ras has been attributed to the induction of replicative growth arrest. This irreversible 'fail-safe mechanism' resembles senescence and requires induction by Ras of p19ARF and p53 (refs 3–5).
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