1. Mark Madine is in the Chromosomal Replication Laboratory, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms , Hertfordshire, EN6 3LD, UK.
   Ron Laskey is in the Wellcome/CRC Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.
   e-mail: madinem@icrf.icnet.uk

Abstract

Recent work has clarified how higher eukaryotic cells 'licence' DNA replication precisely once per cycle. An inhibitor, geminin, prevents replication before mitosis by inhibiting the replication factor Cdt1. Degradation of geminin in anaphase allows Cdt1 to promote binding of MCM proteins, and hence DNA replication.

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