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Nature Cell Biology 3, E46 - E49 (2001)
doi:10.1038/35055152
S-nitrosylation: spectrum and specificity
Douglas T. Hess1, Akio Matsumoto1, Raphael Nudelman1 & Jonathan S. Stamler1
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Douglas T. Hess, Akio Matsumoto, Raphael Nudelman and Jonathan
S. Stamler in the Howard Hughes Medical Institute and the Departments
of Medicine and Biochemistry, Duke University Medical Center,
Durham, North Carolina 27710, USA.
e-mail: staml001@mc.duke.edu
Abstract
Nitric oxide regulates a broad functional spectrum of proteins by S-nitrosylation. Specificity is conferred by acid–base and hydrophobic motifs that target critical cysteine residues and by protein–protein interactions that confine the signals in space.
