Article abstract
Nature Cell Biology 3, 158 - 164 (2001)
Published online: 17 January 2001 | doi:10.1038/35055065
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
Takao Iwawaki1, Akira Hosoda1, Tetsuo Okuda1, Yusuke Kamigori1, Chizumi Nomura-Furuwatari1, Yukio Kimata1,2, Akio Tsuru1,2 & Kenji Kohno1,2
Abstract
Under conditions of endoplasmic reticulum (ER) stress, mammalian cells induce both translational repression and the unfolded protein response that transcriptionally activates genes encoding ER-resident molecular chaperones. To date, the only known pathway for translational repression in response to ER stress has been the phosphorylation of eIF-2
by the double-stranded RNA-activated protein kinase (PKR) or the transmembrane PKR-like ER kinase (PERK). Here we report another pathway in which the ER transmembrane kinase/ribonuclease IRE1
induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. The evidence suggests that both pathways are important for efficient translational repression during the ER stress response.
- Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara 630-0101, Japan
- CREST, Japan Science and Technology Corporation, 2-3, Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan
Correspondence to: Kenji Kohno1,2 e-mail: kkouno@bs.aist-nara.ac.jp
