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Nature Cell Biology 3, E270 - E272 (2001)
doi:10.1038/ncb1201-e270
Deconstructing desmoplakin
Sarah Hatsell1 & Pamela Cowin1
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Sarah Hatsell and Pamela Cowin are in the Departments of Cell Biology and Dermatology, New York University School of Medicine, 550 First Ave, New York, New York 10016, USA
e-mail: hatses01@med.nyu.edu
e-mail: cowinp01@med.nyu.edu
Abstract
Mature desmosomes are the main adhesive junctions in epithelia and cardiac muscle. Now new work shows that the desmosomal protein desmoplakin is also essential for the maturation of adherens junctions. Desmoplakin clamps down on the transient zippering courtship of the classical cadherins, promoting the maturation of puncta adherens junctions and cortical actin remodelling, steps that are essential for cell adhesion.
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