Amnon Harel and Douglass J. Forbes are in the Section of Cell and Developmental Biology, Division of Biology 0347, University of California, San Diego, La Jolla, California 92093-0347, USA
dforbes@ucsd.edu
Individual viruses have evolved strategies for surmounting a formidable barrier in their path to replication in the nucleus — the nuclear envelope. A new study describing the nuclear entry of adenovirus 2 finds that this virus docks at the CAN/Nup214 protein of the nuclear pore, then hijacks histone H1 and specific H1-import receptors to effect a targeted uncoating of its nucleocapsid at the nuclear pore.
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