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Nature Cell Biology 3, E228 (1 October 2001) | doi:10.1038/ncb1001-e228

Moving on up and down

Sarah Greaves

α-Herpesviruses, such as herpes simplex virus, the cause of coldsores, have an unusual life cycle within their chosen hosts. These viruses infect a primary epithelial site within a host, such as the skin around the mouth, and then move into the cell body of the neuron innervating this area.