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Nature Cell Biology 3, E232 - E233 (2001)
doi:10.1038/ncb1001-e232

Ubiquitination, proteasomes and GABAA receptors

Bernhard Lüscher1 & Cheryl A. Keller1

  1. Bernhard Lüscher and Cheryl A. Keller are in the Department of Biology and the Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    e-mail: BXL25@psu.edu

Inhibitory neurotransmission by gamma-aminobutyric acid (GABA) is regulated by the number and subcellular localization of GABAA receptors in the membrane of the target neuron. A new study suggests that the ubiquitin-like protein Plic-1 stabilizes intracellular GABAA receptors and promotes their accumulation in the plasma membrane.

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RESEARCH
GABAA receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1
Nature Neuroscience Article (01 Sep 2001)

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