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Nature Cell Biology 3, E229 - E231 (2001)
doi:10.1038/ncb1001-e229
Sugar-coated pathways for developmental patterning
Mark E. Fortini1
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Mark Fortini is in the Department of Genetics, University of Pennsylvania School of Medicine, Stellar-Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
e-mail: fortini@mail.med.upenn.edu
Abstract
Signalling pathways controlling developmental cell fate rely on a variety of carbohydrate-based protein modifications, including glycosylation of cell-surface and extracellular-matrix proteins. Receptors themselves might be glycosylated during synthesis and secretory trafficking, regulating their subsequent signalling activities. Two recent reports have uncovered a shared requirement for nucleotide–sugar transport in these processes, underscoring the importance of carbohydrates in developmental patterning.
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