Focus on cell division - pE1

doi:10.1038/35050631

Full Text - Focus on cell division | PDF (83 KB) - Focus on cell division

Re-staging mitosis: a contemporary view of mitotic progression - ppE3 - E6

Jonathon Pines & Conly L. Rieder

doi:10.1038/35050676

The process of cell division, or mitosis, has fascinated biologists since its discovery in the late 1870s. Progress through mitosis is traditionally divided into stages that were defined over 100 years ago from analyses of fixed material from higher plants and animals. However, this terminology often leads to ambiguity, especially when comparing different systems. We therefore suggest that mitosis can be re-staged to reflect more accurately the molecular pathways that underlie key transitions.

Full Text - Re-staging mitosis: a contemporary view of mitotic progression | PDF (1,982 KB) - Re-staging mitosis: a contemporary view of mitotic progression

Cell polarity: the PARty expands - ppE7 - E9

Chris Q. Doe

doi:10.1038/35050684

Recent work has revealed an evolutionarily conserved trio of proteins that regulate cell polarity in epithelial cells, embryonic blastomeres and neural precursors. This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors.

Full Text - Cell polarity: the PARty expands | PDF (108 KB) - Cell polarity: the PARty expands

Rab6-KIFL in a pinch - pE9

Angela Eggleston

doi:10.1038/35050688

Full Text - Rab6-KIFL in a pinch | PDF (51 KB) - Rab6-KIFL in a pinch

Shedding a little light on light chains - ppE10 - E12

Daniel P. Mulvihill & Jeremy S. Hyams

doi:10.1038/35050634

Myosin II regulatory light chains have an important role in the organization and function of the contractile machinery at cytokinesis. Two recent reports provide new insights into these important proteins.

Full Text - Shedding a little light on light chains | PDF (93 KB) - Shedding a little light on light chains

Tumour-suppressor genes prosper during asymmetric division - pE11

Sarah Greaves

doi:10.1038/35050638

Full Text - Tumour-suppressor genes prosper during asymmetric division | PDF (449 KB) - Tumour-suppressor genes prosper during asymmetric division

Together until separin do us part - ppE12 - E14

Angelika Amon

doi:10.1038/35050642

Loss of sister-chromatid cohesion triggers chromosome segregation. Several recent reports show that the protease Esp1 cleaves the cohesin subunit Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates. This finding indicates that cohesin cleavage may control sister-chromatid separation in all eukaryotes.

Full Text - Together until separin do us part | PDF (84 KB) - Together until separin do us part

A roar for INCENP - pE14

Sarah Greaves

doi:10.1038/35050646

Full Text - A roar for INCENP | PDF (577 KB) - A roar for INCENP

Different faces of the cell cycle - pE15

doi:10.1038/35050649

Full Text - Different faces of the cell cycle | PDF (900 KB) - Different faces of the cell cycle

Cycling through the World Wide Web - pE16

doi:10.1038/35050654

Full Text - Cycling through the World Wide Web | PDF (57 KB) - Cycling through the World Wide Web

The spindle: a dynamic assembly of microtubules and motors - ppE28 - E34

Torsten Wittmann, Anthony Hyman & Arshad Desai

doi:10.1038/35050669

Abstract - | Full Text - The spindle: a dynamic assembly of microtubules and motors | PDF (519 KB) - The spindle: a dynamic assembly of microtubules and motors

Cycling through development in Drosophila and other metazoa - ppE35 - E39

Smruti J Vidwans & Tin Tin Su

doi:10.1038/35050681

Abstract - | Full Text - Cycling through development in Drosophila and other metazoa | PDF (136 KB) - Cycling through development in Drosophila and other metazoa

DAP kinase activates a p19^ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation - pp1 - 7

Tal Raveh, Gustavo Droguett, Marshall S. Horwitz, Ronald A. DePinho & Adi Kimchi

doi:10.1038/35050500

Abstract - | Full Text - DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation | PDF (395 KB) - DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1 - pp8 - 14

Toshimasa Ishizaki, Yosuke Morishima, Muneo Okamoto, Tomoyuki Furuyashiki, Takayuki Kato & Shuh Narumiya

doi:10.1038/35050598

Abstract - | Full Text - Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1 | PDF (2,047 KB) - Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1 | Supplementary information

FRAP reveals that mobility of oestrogen receptor- is ligand- and proteasome-dependent - pp15 - 23

David L. Stenoien, Kavita Patel, Maureen G. Mancini, Martin Dutertre, Carolyn L. Smith, Bert W. O'Malley & Michael A. Mancini

doi:10.1038/35050515

Abstract - | Full Text - FRAP reveals that mobility of oestrogen receptor- is ligand- and proteasome-dependent | PDF (2,328 KB) - FRAP reveals that mobility of oestrogen receptor- is ligand- and proteasome-dependent

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation - pp24 - 29

Nathan W. Bays, Richard G. Gardner, Linda P. Seelig, Claudio A. Joazeiro & Randolph Y. Hampton

doi:10.1038/35050524

Abstract - | Full Text - Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation | PDF (355 KB) - Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation

Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor - pp30 - 37

Abhijit Mazumdar, Rui-An Wang, Sandip K. Mishra, Liana Adam, Rozita Bagheri-Yarmand, Mahitosh Mandal, Ratna K. Vadlamudi & Rakesh Kumar

doi:10.1038/35050532

Abstract - | Full Text - Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor | PDF (777 KB) - Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor | Supplementary information

Multi-step control of spindle pole body duplication by cyclin-dependent kinase - pp38 - 42

Steven B. Haase, Mark Winey & Steven I. Reed

doi:10.1038/35050543

Abstract - | Full Text - Multi-step control of spindle pole body duplication by cyclin-dependent kinase | PDF (249 KB) - Multi-step control of spindle pole body duplication by cyclin-dependent kinase

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila - pp43 - 49

Mark Petronczki & Juergen A. Knoblich

doi:10.1038/35050550

Abstract - | Full Text - DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila | PDF (1,391 KB) - DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division - pp50 - 57

Yohanns Bellaïche, Michel Gho, Julia A. Kaltschmidt, Andrea H. Brand & François Schweisguth

doi:10.1038/35050558

Abstract - | Full Text - Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division | PDF (2,549 KB) - Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division | Supplementary information

Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage - pp58 - 67

Fabrice Roegiers, Susan Younger-Shepherd, Lily Yeh Jan & Yuh Nung Jan

doi:10.1038/35050568

Abstract - | Full Text - Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage | PDF (1,680 KB) - Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage | Supplementary information

Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization - pp68 - 75

Victoria A. Stevenson, Joseph Kramer, Jesse Kuhn & William E. Theurkauf

doi:10.1038/35050579

Abstract - | Full Text - Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization | PDF (1,306 KB) - Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization | Supplementary information

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex - pp76 - 82

Jean-Baptiste Marchand, Donald A. Kaiser, Thomas D. Pollard & Henry N. Higgs

doi:10.1038/35050590

Abstract - | Full Text - Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex | PDF (686 KB) - Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex | Supplementary information

The APC is dispensable for first meiotic anaphase in Xenopus oocytes - pp83 - 87

Marion Peter, Anna Castro, Thierry Lorca, Christian Le Peuch, Laura Magnaghi-Jaulin, Marcel Dorée & Jean-Claude Labbé

doi:10.1038/35050607

Abstract - | Full Text - The APC is dispensable for first meiotic anaphase in Xenopus oocytes | PDF (343 KB) - The APC is dispensable for first meiotic anaphase in Xenopus oocytes

Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowth - pp88 - 92

Steven R. Wylie & Peter D. Chantler

doi:10.1038/35050613

Abstract - | Full Text - Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowth | PDF (781 KB) - Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowth

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins - pp93 - 96

Patrice Connell, Carol A. Ballinger, Jihong Jiang, Yaxu Wu, Larry J. Thompson, Jörg Höhfeld & Cam Patterson

doi:10.1038/35050618

Abstract - | Full Text - The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins | PDF (234 KB) - The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins | Supplementary information

A Ran-independent pathway for export of spliced mRNA - pp97 - 99

K. Nicole Clouse, Ming-juan Luo, Zhaolan Zhou & Robin Reed

doi:10.1038/35050625

Abstract - | Full Text - A Ran-independent pathway for export of spliced mRNA | PDF (193 KB) - A Ran-independent pathway for export of spliced mRNA

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation - pp100 - 105

Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang, J. Michael Younger & Douglas M. Cyr

doi:10.1038/35050509

Abstract - | Full Text - The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation | PDF (695 KB) - The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation