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Together until separin do us part

Nature Cell Biology volume 3, pages E12–E14 (2001)Cite this article

Loss of sister-chromatid cohesion triggers chromosome segregation. Several recent reports show that the protease Esp1 cleaves the cohesin subunit Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates. This finding indicates that cohesin cleavage may control sister-chromatid separation in all eukaryotes.

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Figure 1: Control of sister-chromatid cohesion in yeast and vertebrates.

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  1. the Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA

    Angelika Amon

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  1. Angelika Amon
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Amon, A. Together until separin do us part. Nat Cell Biol 3, E12–E14 (2001). https://doi.org/10.1038/35050642

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