Historical Perspective abstract


Nature Cell Biology 3, E17 - E21 (2001)
doi:10.1038/35050656

Mitosis: a history of division

T. J. Mitchison1 & E. D. Salmon2


Mitosis has been studied since the early 1880s, to the extent that we now have a detailed, but still incomplete, description of spindle dynamics and mechanics, a sense of potential mechanochemical and regulatory mechanisms at a molecular level, and a long list of mitotic proteins. Here we present a personal view of how far we have come, and where we need to go to fully understand the mechanisms involved in mitosis.

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  1. Timothy Mitchison is in the Deparment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
  2. Edward. D. Salmon is in the Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    e-mail: timothy_mitchison@hms.harvard.edu



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