focus on cell division
Nature Cell Biology 3, E12 - E14 (2001)
doi:10.1038/35050642
Together until separin do us part
Angelika Amon1
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Angelika Amon is at the Center for Cancer Research,
Howard Hughes Medical Institute, Massachusetts Institute of Technology,
Cambridge, Massachusetts 02139, USA
e-mail: angelika@mit.edu
Abstract
Loss of sister-chromatid cohesion triggers chromosome segregation. Several recent reports show that the protease Esp1 cleaves the cohesin subunit Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates. This finding indicates that cohesin cleavage may control sister-chromatid separation in all eukaryotes.
