Angelika Amon is at the Center for Cancer Research,
Howard Hughes Medical Institute, Massachusetts Institute of Technology,
Cambridge, Massachusetts 02139, USA
angelika@mit.edu
Loss of sister-chromatid cohesion triggers chromosome segregation.
Several recent reports show that the protease Esp1 cleaves the cohesin subunit
Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates.
This finding indicates that cohesin cleavage may control sister-chromatid
separation in all eukaryotes.
