1. Frauke Melchior and Ludger Hengst are at the Max Planck Institute for Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany. e-mail: melchior@biochem.mpg.de ; e-mail: hengst@biochem.mpg.de

Abstract

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53.

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