Table of contents


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Editorial

In search of a function ppE137 - E138

doi:10.1038/35019607


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News and Views

Ubiquitin biology: an old dog learns an old trick ppE139 - E141

Cecile M. Pickart

doi:10.1038/35019610


Growth and polarity: the case for Scribble pE140

Sarah Greaves

doi:10.1038/35019613


LAP proteins: what's up with epithelia? ppE141 - E143

Peter J. Bryant & Adrien Huwe

doi:10.1038/35019616


Cell polarity: new PARtners for Cdc42 and Rac ppE143 - E145

Stuart K. Kim

doi:10.1038/35019620


The consequences of incontinentia pigmenti pE144

Sarah Greaves

doi:10.1038/35019623


Multi-layered regulation of courtship behaviour ppE145 - E146

Steven A. Wasserman

doi:10.1038/35019626


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Book Reviews

Honest Jim pE148

Robert Weinberg reviews A Passion for DNA "Genes, Genomes and Society" by James D. Watson

doi:10.1038/35019630


Deciphering the structure of living beings pE149

Paolo Mazzarello reviews The Birth of the Cell by Henry Harris

doi:10.1038/35019633


Negative thinking: anion channels claim their rights pE150

Michael Pusch reviews Chloride Channels by Roland Kozlowski

doi:10.1038/35019636


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Historical Perspective

Lessons from the history of light microscopy ppE151 - E152

Brad Amos

doi:10.1038/35019639


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Review

Evolution and function of ubiquitin-like protein-conjugation systems ppE153 - E157

Mark Hochstrasser

doi:10.1038/35019643


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Articles

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome pp469 - 475

Helen M. Beere, Beni B. Wolf, Kelvin Cain, Dick D. Mosser, Artin Mahboubi, Tomomi Kuwana, Pankaj Tailor, Richard I. Morimoto, Gerald M. Cohen & Douglas R. Green

doi:10.1038/35019501


Negative regulation of the Apaf-1 apoptosome by Hsp70 pp476 - 483

Ayman Saleh, Srinivasa M. Srinivasula, Levent Balkir, Paul D. Robbins & Emad S. Alnemri

doi:10.1038/35019510


CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint pp484 - 491

Xuebiao Yao, Ariane Abrieu, Yun Zheng, Kevin F. Sullivan & Don W. Cleveland

doi:10.1038/35019518


Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation pp492 - 499

Tomoyuki Tanaka, Jörg Fuchs, Josef Loidl & Kim Nasmyth

doi:10.1038/35019529


Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression pp500 - 506

Kazue Usui-Aoki, Hiroki Ito, Kumiko Ui-Tei, Kuniaki Takahashi, Tamas Lukacsovich, Wakae Awano, Hiromi Nakata, Zheng Fu Piao, Eric E. Nilsson, Jun-ya Tomida & Daisuke Yamamoto

doi:10.1038/35019537

See also: News and Views by Wasserman


Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization pp507 - 514

Evgeny Kobrinsky, Tooraj Mirshahi, Hailin Zhang, Taihao Jin & Diomedes E. Logothetis

doi:10.1038/35019544


Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 pp515 - 520

Carol Hicks, Stuart H. Johnston, Guy diSibio, Andres Collazo, Thomas F. Vogt & Gerry Weinmaster

doi:10.1038/35019553


p95-APP1 links membrane transport to Rac-mediated reorganization of actin pp521 - 530

Alessandra Di Cesare, Simona Paris, Chiara Albertinazzi, Simona Dariozzi, Jens Andersen, Matthias Mann, Renato Longhi & Ivan de Curtis

doi:10.1038/35019561


The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 pp531 - 539

Gérard Joberty, Clark Petersen, Lin Gao & Ian G. Macara

doi:10.1038/35019573

See also: News and Views by Kim


A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity pp540 - 547

Dan Lin, Amelia S. Edwards, James P. Fawcett, Geraldine Mbamalu, John D. Scott & Tony Pawson

doi:10.1038/35019582

See also: News and Views by Kim


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Brief Communications

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish pp549 - 552

Qiaoming Long, Haigen Huang, Ebrahim Shafizadeh, Ningai Liu & Shuo Lin

doi:10.1038/35019592


BAX-dependent transport of cytochrome c reconstituted in pure liposomes pp553 - 555

Mitsuyoshi Saito, Stanley J. Korsmeyer & Paul H. Schlesinger

doi:10.1038/35019596


Anaphase spindle position is monitored by the BUB2 checkpoint pp556 - 558

Andrew Bloecher, Guglielmo M. Venturi & Kelly Tatchell

doi:10.1038/35019601


The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation pp559 - 562

Lan Xu, Ye-Guang Chen & Joan Massagué

doi:10.1038/35019649


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