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Nature Cell Biology 2, E121–E123 (1 July 2000) | doi:10.1038/35017129
VHL takes HIF|[rsquo]|s breath away
Abstract
Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
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