News and Views abstract
Nature Cell Biology 2, E121 - E123 (2000)
doi:10.1038/35017129
VHL takes HIF's breath away
Wilhelm Krek1
- Wilhelm Krek is at the Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Correspondence to: Wilhelm Krek1 e-mail: wilhelm.krek@fmi.ch
Abstract
Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the 
-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
