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Nature Cell Biology  2, E121 - E123 (2000)
doi:10.1038/35017129

VHL takes HIF's breath away

Wilhelm Krek

Wilhelm Krek is at the Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

Correspondence should be addressed to Wilhelm Krek wilhelm.krek@fmi.ch
Inactivation of the von Hippel−Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel−Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.

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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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