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Nature Cell Biology 2, E95 (1 June 2000) | doi:10.1038/35014087
Convergence of DNA repair and cell-cycle checkpoint control
Abstract
Eukaryotic cells have two pathways for DNA repair - the first, homologous recombination, depends upon the presence of homologous DNA, such as sister chromatids, whereas the second, non-homologous end joining, is capable of fusing any broken DNA ends. Deficiencies in a cell|[rsquo]|s ability to carry out DNA repair can cause susceptibility to cancer.
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