News and Views abstract
Nature Cell Biology 2, E98 - E100 (2000)
doi:10.1038/35014091
Different site, different splice
Tom Misteli1
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Tom Misteli is at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
e-mail: mistelit@mail.nih.gov
Abstract
The MKK3/6–p38 pathway has been found to induce the relocalization of premessenger-RNA splicing factors from the nucleus to the cytoplasm. This represents the first physiological mechanism that alters the nuclear ratios of splicing factors and modulates alternative splice-site choice in vivo.
