Karine F. Ferri and Guido Kroemer are at the Apoptosis, Cancer and Immunity Laboratory associated with the National League against Cancer, CNRS-UMR 1599, Institut Gustave Roussy, 39 rue Calmette Desmoulins, F-94805 Villejuif, France.
Apoptotic DNA degradation has been thought to be a cell-autonomous process. Recent evidence suggests that heterophagic recognition and engulfment of dying cells by non-apoptotic cells may be critical for the activation and/or action of apoptogenic DNases.
