News and Views abstract
Nature Cell Biology 2, E39 - E41 (2000)
doi:10.1038/35004065
The ins and outs of cell-polarity decisions
Erin K. O'Shea1 & Ira Herskowitz2
- e-mail: oshea@biochem.ucsf.edu
-
Erin K. O'Shea and Ira Herskowitz are at the
University of California San Francisco, Department of Biochemistry & Biophysics
, 513 Parnassus Avenue, San Francisco,
California 94143-0448, USA.
e-mail: ira@cgl.ucsf.edu
Abstract
The guanine-nucleotide-exchange factor Cdc24 is a critical regulator of cell polarity. Far1 is a key player in Cdc24 regulation, controlling Cdc24 activity in budding yeast by regulating its subcellular localization in response to two very different signals — one external and one internal.
