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cover image Synchronous chromosome segregation in an early Drosophila embryo. Spindle microtubules are shown in red, DNA is in green, and the centrosomal protein g-tubulin is in blue. DNA damage and DNA-replication defects trigger mitosisspecific dissociation of g-tubulin from the centrosome and block chromosome segregation. [Cover design: Majo Xeridat] [article, p.90; news and views, p.E28]