Review abstract
Nature Cell Biology 2, E231 - E236 (2000)
doi:10.1038/35046659
Paxillin and focal adhesion signalling
Christopher E. Turner1
Abstract
To facilitate a rapid response to environmental change, cells use scaffolding — or adaptor — proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.
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Department of Cell and Developmental Biology, SUNY
Upstate Medical University, 750 East Adams Street,
Syracuse, New York 13210, USA.
e-mail: turnerc@mail.upstate.edu
