The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.
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Khalaj, M., Park, C. snoRNAs contribute to myeloid leukaemogenesis. Nat Cell Biol 19, 758–760 (2017). https://doi.org/10.1038/ncb3566
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DOI: https://doi.org/10.1038/ncb3566
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